摘要
[目的]研究疏风饮对2,4-二硝基氯苯(DNCB)诱导的小鼠变应性接触性皮炎(ACD)的影响。[方法]利用DNCB诱导建立小鼠变应性接触性皮炎模型,观察疏风饮对小鼠脾指数与胸腺指数的影响,ELISA检测各组小鼠血清中γ-干扰素(IFN-γ)与白细胞介素-4(IL-4)的含量。[结果]疏风饮对DNCB所致的ACD小鼠的脾指数与胸腺指数的升高有抑制作用,降低小鼠血清中IFN-γ的含量,提高IL-4的含量。[结论]疏风饮对DNCB诱导的小鼠变应性接触性皮炎的抑制作用及其机制与调节细胞因子的分泌有关。
[Objective] To explore the effect of ShuFengYin treating allergic contact dermatitis （ACD） mice caused by hydrophobic drink 2, 4 - dinitrophenol nitro chlorobenzene （ DNCB ）. [ Methods ] ACD model by DNCB induction established. To observe the effects of spleen index （PI） and thymus index （TI） caused by ShuFengYin ; ELISA was used to investigate the expression of interferon - gamma（ IFN - γ） and interleukin - 4 （IL- 4）. r Results ] ShuFengYin can restrain the increase of PI and TI and reduce IFN -γ and improve IL- 4 content of mice serum. [ Conclusion] The machinism of inhibition effects for mice＇ACD caused by ShuFengY- in decided by Regulating cell＇s secretion.
出处
《实用中医内科杂志》
2011年第1期24-25,共2页
Journal of Practical Traditional Chinese Internal Medicine
作者简介
通信作者
