摘要
目的 探讨晚发型单相抑郁症的遗传实方式.方法 采用严格的纳入标准,对符合中国精神疾病分类方案与诊断标准第3版（CCMD-3）抑郁发作诊断标准,首次发病年龄＞30岁的68例单相抑郁症患者用医学遗传数学方法中分离分析和多基因阈值理论进行遗传实方式的研究.结果 晚发型一级亲属单相抑郁症加权平均遗传率及标准误为（75.7±1.2）%,预期发病率为5.0%,与实际发病率3.6 %相比较无显著性差异（u=1.5,P＞0.05）.结论 晚发型单相抑郁症的遗传方式符合多基因遗传.
Objective To investigate the mode of inheritance of late onset unipolar depression. Methods Sixty--eight subjects who met CCMD--3 diagnostic criteria for depressive episode which begin after 30 years old and their family were studied using segregation analysis and polygenic threshold theory. Results The weighted mean of the heritability and standard error was（75.7±1.2）. The expected in- cidence was 5.0% which was not significantly different from the incidence of 3.6% in their first-degree relatives. Conclusions The results suggest that the mode of inheritance of late onset unipolar de pression was in conformity to multifactorial inheritance.
出处
《神经疾病与精神卫生》
2010年第6期572-574,共3页
Journal of Neuroscience and Mental Health
关键词
晚发型
单相抑郁症
遗传方式
Late--onset
Unipolar depression
Genetic model
