摘要
目的探讨首发抑郁症的遗传效应及方式。方法对107例首发抑郁症患者的一至三级亲属(共4439人)进行家族史调查,用分离分析和多基因阈值理论进行遗传方式研究。结果(1)先证者中有精神疾病家族史者占430%(46例),其中有抑郁症家族史者占有精神疾病家族史者的61%(28/46)。(2)一至三级亲属中抑郁症的患病率为087%(29例),高于群体患病率(002%;P<001);其中女性患病率(136%)高于男性(041%,P<001)。一、二、三级亲属患病率分别为746%、037%和005%,前两者均高于群体患病率(P<001);各级亲属的女性患病率均高于男性,其中一级亲属女性患病率为1612%,男性患病率为844%(P<001)。(3)校正后分离率为020,与隐性遗传分离率025比较,差异无统计学意义(P>005);加权平均遗传率及标准误为(10973±526)%;一、二、三级亲属的预期患病率分别为720%、062%和013%,与实际患病率(分别为747%、037%和005%)比较,差异均无统计学意义。结论首发抑郁症具有明显的遗传效应,可能符合具有隐性主基因效应的多基因遗传方式。
Objective To probe into the genetic effects and genetic mode of first-episode depression.Methods According to strict inclusion and exclusion criteria, 107 cases diagnosed of first-episode depression were studied using family history method. A mathematic method in medical genetics, including segregation analysis and the multifactorial threshold theory, was applied for the research into the inheritance mode.Results (1) In all the pedigrees investigated, 28 probands had family history of depression, higher than that of other psychiatric disorders. (2) The prevalence of first-episode depression in the proband's relatives was 0.87%, higher than 0.02% in general population from the epidemic survey in the seven areas of China in 1993 (P<0.01). The prevalence of depression in the first-, second-and third-degree relatives were 7.46%, 0.37%, and 0.05%, respectively. (3) The adjusted segregative rate was 0.20, and it was not significantly different from the rate of 0.25 in autosome recessive inheritance. The weighted mean of the heritability and standard error was (109.73±5.26)%. The expected prevalence was not significantly different from the real prevalence.Conclusion First-episode depression has evident genetic effect, its mode of inheritance may conform to polygenic inheritance with a major autosome recessive gene.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2005年第1期7-10,共4页
Chinese Journal of Psychiatry
基金
国家自然科学基金资助项目(30270729)
