摘要
目的:研究洋金花(Datura metel L.)的化学成分。方法:采用 50%乙醇提取, 利用硅胶、Sephadex LH-20、ODS 柱层析和 HPLC 等方法进行分离和纯化, 依据核磁数据分析进行结构鉴定。结果:分离得到 9 个化合物, 分别鉴定为(+)松脂酚-O-β-D-双葡萄吡喃糖苷(1), (+)松脂酚-O-β-D-葡萄吡喃糖苷(2), 对羟基苯乙醇(3), N-p-香豆酰酪胺(4), 顺式-N-p-香豆酰酪胺(5), N-对羟基苯乙基-对羟基苯甲酰胺(6), 苯乙醇-O-β-D-葡萄吡喃糖基(2→1)-O-β-D-葡萄吡喃糖苷(7), 3-O-[β-D-葡萄吡喃糖基(1→2)]-β-D-半乳糖基-7-O-α-L-鼠李吡喃糖基-山柰酚(8), 3-O-[β-D-葡萄吡喃糖基(1→2)]-β-D-葡萄吡喃糖基-7-O-β-D-葡萄吡喃糖基-山柰酚(9)。结论:化合物 1～9 均为首次从该植物中分离得到。
AIM： To study the chemical constituents of Datura metel L. METHODS： Extracted with 50% EtOH, the constituents were isolated and purified by silica gel, ODS and Sephadex LH-20 column chromatography as well as HPLC. Their chemical structures were elucidated on the basis of spectral data. RESULTS： Nine compounds were isolated and identified as （＋）-pinoresinol-O-β-D-diglucopyranoside （1）, （＋）-pinoresinol-O-β-D-glucopyranoside （2）, p-tyrosol （3）, trans-N-p-coumaroyltyramine （4）, cis-N-p-coumaroyltyramine （5）, 4-hydroxy-N-（4-hydroxyphenethyl） benzamide （6）, phenethyl alcohol-O-β-D-glucopyranosyl-（2→1）-O-β-D-glucopyranoside （7）, kaempferol-3-O-β-D-glucopyranosyl-（1→2）-β-D-galactopyranosyl-7-O-α-L-rhamnopyranoside （8）, and kaempferol-3-O-β-D-glucopyranosyl-（1→2）- β-D-galactopyranosyl-7-O-β-D-glucopyranoside （9）. CONCLUSION： Compounds 1-9 have been isolated from this plant for the first time. [
出处
《中国天然药物》
SCIE
CAS
CSCD
北大核心
2010年第6期429-432,共4页
基金
supported by the Major State Basic Research Development Program of China (973 Pro-gram 2006CB504708)
the National Natural Science Foundation of China (Nos 30371736, 30672633)
Special Fund Project of National Excellent Doctoral Dissertation of China (200980)
关键词
洋金花
化学成分
结构鉴定
] Datura metel L.
Chemical constituents
Structure determination
作者简介
KUANG Hai-Xue： Prof., Tel： 86-451- 82193001, E-mail： hxkuang@hotmail.com
