摘要
多囊卵巢综合征(PCOS)是育龄期妇女常见的生殖内分泌疾病,其病因及发病机制复杂,尽管提出了很多假说,但其确切的发病机制仍不十分清楚。近年研究显示,肿瘤坏死因子α(TNF-α)与该病关系密切,其参与胰岛素抵抗、高雄激素血症、肥胖、排卵障碍以及黄体功能不全等多个方面。就TNF-α在PCOS代谢异常中的作用及对卵巢功能的影响做文献综述。
Polycystic ovary syndrome（PCOS） is a common disease among reproductive-aged women.The etiology and pathogenesis of PCOS is complex,although a lot of hypothesis have been proposed,the exact mechanism is still unclear.Recent of studies have suggested that the tumor necrosis factor-α involved in insulin resistance,hyperandrogenism,obesity,ovulation failure and corpus luteum insufficiency of PCOS.This review briefly introduced the tumor necrosis factor-α′s action in the metabolic disorder and the effect of ovarian function in PCOS.
出处
《国际妇产科学杂志》
CAS
2010年第6期412-415,共4页
Journal of International Obstetrics and Gynecology
关键词
多囊卵巢综合征
肿瘤坏死因子Α
胰岛素抗药性
肥胖症
糖尿病
Polycystic ovary syndrome
Tumor necrosis factor-alpha
Insulin resistance
Obesity
Diabetes mellitus
作者简介
通讯作者：马红霞．E—mail：doctormaxia_1974@yahoo．com．cn
