摘要
酒精性脂肪肝(AFLD)是由于长期大量饮酒导致肝脏脂肪代谢紊乱,并大量沉积的一种代谢性疾病。过氧化物酶增殖物激活受体-α(PPARα)是一类配体激活的核转录因子超家族成员之一,高表达于肝脏。研究发现,PPARα与乙醇代谢,以及肝脏脂肪代谢密切相关。乙醇影响PPARα的正常功能,而PPARα的缺失或表达受抑参与了酒精性肝损伤的过程,促进了肝细胞脂肪变性及炎症的发生、发展。另外,PPARα参与脂质分解代谢的多个方面,包括脂肪酸的透膜吸收、脂肪酸在细胞内的结合、脂肪酸的氧化及脂蛋白的合成与运输。PPARα及其特异性配体的运用将会成为AFLD治疗的一个新靶点。论文综述了PPARα的结构、生物学作用及其在AFLD发生机制中的作用,可为该病的治疗提供新的思路。
Alcoholic fatty liver disease(AFLD),a kind of metabolism disease which was caused by long term and large quantity of alcohol abuse,is characterized by fatty metabolic disorder and deposition in the liver.Peroxisome proliferater-activated receptor-α(PPARα) is one of the nuclear factor super family and is highly expressed in the liver.It has been reported that PPARαhad close relationship with alcohol and fatty metabolism in the liver.Alcohol could affect the function of PPARα,meanwhile,the absence and inhibition of PPARα could also participate in the hepatic injury caused by alcohol,promote the steatosis of the hepatocytes and the occurrence and development of inflammation.In addition,PPARα involves in many other processes of fatty catabolism including the absorption,combination,oxidation of fatty acid and synthesis and transmission of lipoprotein.Application of PPARα and its specific ligand would be a new curative target for AFLD.The paper reviewed the effect of PPARαin ALFD,which would provide a new direction for prevetion and cure for AFLD.
出处
《动物医学进展》
CSCD
北大核心
2012年第2期71-74,共4页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31172285)
辽宁省自然科学基金(20072123)
辽宁省科学技术计划(2009408002)
关键词
酒精性脂肪肝
过氧化物酶增殖物激活受体-α
乙醇代谢
脂肪代谢
肝损伤
alcoholic fatty liver disease
peroxisome proliferater-activated receptor-α
alcohol metabolism
fatty metabolism
hepatic injury
作者简介
陶妍(1986-),女(蒙古族),内蒙古呼伦贝尔人,硕士研究生,主要从事动物生理与生殖内分泌学研究。
通讯作者