摘要
目的广东汉族3大民系即潮汕、广府和客家人都是内陆中原汉族移民的后裔,本研究利用反映母系遗传的线粒体DNA(mtDNA)证据分析3大民系的遗传背景差异。方法收集89份潮汕人血样和48份内陆中原河南太行山食管癌高发区人群血样,构建每个个体的mtDNA单倍群;广府和客家人的单倍群数据来自文献。将这3大民系人群的单倍群分布情况与河南太行山人群和南方原住民族人群进行比较分析。结果河南太行山人主要由北方汉族主要单倍群构成,广府和客家人则以南方原住民族主要单倍群为主,潮汕人表现为北方汉族主要单倍群稍高于南方原住民族主要单倍群。基于单倍群频率的主成分分析显示,河南太行山和潮汕人聚在一起,客家和广府人则与南方原住民族群体聚在一起。结论 3大民系中,只有潮汕人的中原汉族血统更纯正,与河南太行山人群的关系最近,这可能也是其为南方沿海食管癌高危人群的原因之一;而客家和广府人则与南方原住民族在母系血统上有更多的交融。
Objective Three ethnic populations of Han inhabitants in Guangdong Province,namely,Chaoshan population,Cantonese and Hakka,descended from north-central China Han immigrants.Here we analyzed their genetic background differences based on mitochondrial DNA（mtDNA） evidences reflecting matrilineal genetics.Methods Based on mtDNA variations,we inferred mtDNA haplogroups of 48 and 89 subjects from the Taihang and Chaoshan areas,respectively.mtDNA data of Cantonese and Hakka populations were quoted from published literature.We compared haplogroup distribution in the 3 ethnic populations with that in the Taihang Mountain population and the southern natives.Results The northern Han-dominating haplogroups were predominant in the Taihang Mountain population,while Cantonese and Hakka populations had southern natives-dominating haplogroups as their major haplogroups,and Chaoshan population possessed slightly higher frequency of northern haplogroups than southern haplogroups.The principal component analysis based on frequencies of mtDNA haplogroups showed that the Taihang Mountain population and Chaoshan population clustered together,and that Cantonese,Hakka and the southern natives clustered together.Conclusion Of the 3 ethnic populations,Chaoshan population alone possesses the purest lineage of north-central China Hans,and shows the closest genetic affinity to the Taihang Mountain population,which might be one of the reasons why Chaoshan population alone has become esophageal cancer high-risk population in the coast of southern China.Both Cantonese and Hakka populations show more gene flow from the southern natives in the maternal lineage.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第6期664-668,共5页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家自然科学基金国际合作重点项目(No.30210103904)
广东省十五攻关项目(No.A1080203)~~
作者简介
作者简介：李晓昀（1974-），女（汉族），讲师，博士，主要从事食管癌的研究．
通讯作者：苏敏，教授，博士生导师．E-mail：minsu@stu．edu．cn
