摘要
目的探讨遗传因素和环境因素在山西省食管癌发生发展中的作用,为食管癌的病因学研究和早期防治提供科学依据。方法采用病例对照研究和家系调查相结合的方法收集资料,调查分析在山西省肿瘤医院住院的658例食管癌病例和658例相应对照的亲属中食管癌发病情况,做家族聚集性分析。对658个食管癌先证者家系应用Li-Mantel-Gart法做分离分析,Falconer法计算遗传度,应用Greenwood和Yule法做出生顺序分析。结果食管癌先证者家系Ⅰ级亲属患病率高于对照家系Ⅰ级亲属,χ^2=18.247 3,P〈0.001;表明山西省食管癌的发生具有家族聚集性。Li-Mantel-Gart法分析结果显示,分离比为0.030 6（95%CI为0.026 8～0.034 4）,表明食管癌属于多基因遗传性疾病。Ⅰ级亲属遗传度为（22.95±5.65）%,Ⅱ级亲属为（5.26±6.22）%,表明食管癌的遗传背景是山西省食管癌的发病因素之一,但不是主要因素。出生顺序分析结果显示,山西省食管癌的发生与出生顺序有一定关系,食管癌好发在出生顺序较早的个体,提示环境因素对食管癌的发生有一定影响。结论山西省食管癌的发生具有家族聚集性,遗传因素在山西省食管癌发生发展中起一定作用,但不是主要因素;环境因素的作用大于遗传因素的作用。
OBJECTIVE To evaluate the role of genetic factor and environmental factor on the occurrence of esophageal cancer in Shanxi and to provide new clues to the etiological study and the early prevention and treatment of esophageal cancer.METHODS Six hundred and fifty-eight cases of esophageal cancer patients diagnosed in Shanxi Cancer Hospital and 658 cases of healthy controls were recruited in the case-control study and their family clustering were analyzed.The inheritance pattern of esophageal cancer was evaluated by Li-Mantel-Gart＇s method;The heritability was calculated with Falconer＇s method;Greenwood and Yule methods was taken to do Birth order study.RESULTS Compared with the control group,the prevalence rate of the esophageal cancer cases＇ first-degree relatives was higher.Family clustering has been proved in esophageal cancer of Shanxi population（χ^2=18.247 3,P〈0.001）.Li-Mantel-Gart method showed that the inheritance pattern of esophageal cancer belongs to polygenetics mode.Segregation ratio was 0.030 6（95%CI：0.026 8-0.034 4）.The heritability of the first-degree relatives was（22.95±5.65）%,and the heritability of the seconddegree relatives was（5.26±6.22）%.It showed that the genetic background of the esophageal cancer was one risk factor of esophageal cancer,but not the main factor.The birth order analysis showed that the occurrence of esophageal cancer in shanxi was relative to birth order and was more easily happen in the older individual.The environmental factor had a certain influence on the occurrence of esophageal cancer.CONCLUSIONS Family clustering has been proved in esophageal cancer of Shanxi population.The genetic background of esophageal cancer is one factor that enhanced risk for esophageal cancer,but not the main factor.The role of environmental factor is greater than the role of genetic factor.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第19期1490-1493,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
与美国NCI合作课题(NO-SC-66211/CQ600211
NCI
NIH
美国)
关键词
食管癌
家族聚集性
遗传模式
出生顺序分析
流行病学
esophageal cancer
family clustering
genetic model
birth order study
epidemiology
作者简介
郭雪蓉，女，山西洪洞人，硕士，主要从事肿瘤流行病学的研究工作。Tel：86-351—4651200 E—mail：xuerongguo20082009@163．com
【通讯作者简介】王国平，男，山西太原人，博士，教授，硕士生导师，主要从事社会医学与卫生事业管理的研究工作。Tel：86-351-4651723 E-mail：zmkt_z@yeah．net
