摘要
目的探讨维持性血液透析患者动脉粥样硬化与微炎症状态及营养不良的关系。方法回顾性分析医院维持性血液透析(MHD)患者43例〔(其中有动脉粥样硬化(AS)者22例,非动脉粥样硬化(N-AS)者21例)〕的AS、炎症指标和营养状况,并以35例年龄、性别相匹配的正常人群为对照组,比较两组AS发生的情况,并对22例MHD患者AS的相关因素进行分析。结果 MHD组AS的发生率、斑块多发性和颈动脉内膜中层厚度(CIMT)显著高于正常对照组;AS组血白蛋白显著低于N-AS组,AS组14例伴有营养不良,N-AS组仅为3例,两组营养状况差异有统计学意义(P<0.01);AS组血C反应蛋白(CRP)、IL-6显著高于N-AS组(P<0.05),血CRP、IL-6与年龄、透析时间亦相关。结论 MHD患者AS的发生与慢性肾衰竭微炎症状态及营养不良密切相关。
OBJECTIVE To investigate the relationships between atherosclerosis（AS） with microinflammation and malnutrition in maintenance hemodialysis（MHD） patients.METHODS A retrospective analysis of our 43 was carried out to determine their MHD patients 〔including 22 cases of AS,and 21 cases of non-atherosclerosis（N-AS）〕 was carried out to determine their AS,inflammatory indicators and nutritional status,vs 35 normal persons with matched age and sex as a control group and compared the AS happened in two groups.And the relevant factors 22 MHD patients with AS were analyzed.RESULTS The AS incidence,multiple plaque and carotid intimal medial thickness（CIMT） wereincreased significantly in of MHD group as compared with the normal control group.AS group was significantly lower than N-AS group in serum albumin,AS group was with 14 cases of malnutrition,N-AS group was only with three cases,the nutritional status of the two groups was statistically significant（P0.01）;the serum CRP and IL-6 increased were much more in AS group the in N-AS group（P0.05）,with were correlated with the age and dialysis time.CONCLUSIONS The exacerbation of AS of chronic renal failure patients treated with MHD is significantly correlated with microinflammatory state and malnutrition.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第19期2947-2949,共3页
Chinese Journal of Nosocomiology
