摘要
目的探讨采用血液灌流联合维持性血液透析治疗慢性肾衰的效果.方法选择泗水县人民医院2021年10月—2022年11月收治的100例慢性肾衰患者为研究对象,以随机数表法将其分为对照组及观察组,各50例.对照组采用维持性血液透析治疗,观察组在此基础上采用血液灌流干预.比较两组患者的肾功能指标、炎症状态甲状旁朱素及血磷.结果治疗后,观察组的尿素氮、肌酐、β2-微球蛋白水平分别为(7.32±1.46)mmol/L、(410.24±63.25)μmol/L、(1.91±0.37)mg/L,均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的C反应蛋白、白细胞介素-2、白细胞介素-6水平分别为(6.46±1.52)mg/L、(112.47±26.74)pg/mL、(72.60±16.17)pg/mL,均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的甲状旁腺素、血磷水平分别为(28.32±5.26)pmol/L、(1.72±0.44)mmol/L,均低于对照组,组间差异有统计学意义(P<0.05).结论慢性肾衰患者采用血液灌流联合维持性血液透析干预可改善肾功能,减轻炎症反应,预防高磷血症.
Objective To investigate the effect of hemoperfusion combined with maintenance hemodialysis in the treatment of chronic renal failure.Methods 100 patients with chronic renal failure admitted to Sishui County People's Hospital from October 2021 to November 2022 were selected as the study objects and were divided into a control group and an observation group by random number table method,with 50 cases each group.The control group received maintenance hemodialysis treatment,and the observation group received hemoperfusion intervention on this basis.The renal function indexes,inflammatory status,parathyroid hormone and blood phosphorus were compared between the two groups.Results After treatment,the levels of urea nitrogen,creatinine andβ2-microglobulin in the observation group were(7.32±1.46)mmol/L,(410.24±63.25)μmol/L and(1.91±0.37)mg/L,respectively,which were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of C-reactive protein,interleukin-2 and interleukin-6 in the observation group were(6.46±1.52)mg/L,(112.47±26.74)pg/mL and(72.60±16.17)pg/mL,respectively,which were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of parathyroid hormone and blood phosphorus in the observation group were(28.32±5.26)pmol/L and(1.72±0.44)mmol/L,respectively,which were lower than those in the control group and the differences between the groups were statistically significant(P<0.05).Conclusion Hemoperfusion combined with maintenance hemodialysis can improve renal function,reduce inflammation and prevent hyperphosphatemia in patients with chronic renal failure.
作者
邵苗苗
SHAO Miaomiao(Department of Nephrology,Sishui County People's Hospital,Jining Shandong,273200,China)
出处
《反射疗法与康复医学》
2024年第3期140-142,共3页
Reflexology And Rehabilitation Medicine
关键词
慢性肾衰
血液灌流
维持性血液透析
肾功能
炎症状态
Chronic renal failure
Hemoperfusion
Maintenance hemodialysis
Renal function
Inflammatory state
作者简介
邵苗苗(1987-),女,济宁泗水人,本科,主治医师,研究方向:肾内科相关疾病诊疗。
