摘要
目的:探讨小而密低密度脂蛋白(sLDL)和血浆同型半胱氨酸(Hcy)与冠心病的发生及冠状动脉病变程度的关系。方法:根据冠状动脉造影的结果依冠状动脉病有无狭窄分为冠心病组和对照组,检测其血浆Hcy、血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)水平,并测定sLDL在低密度脂蛋白中所占的比例,观察冠脉病变程度与Hcy及sLDL的关系。结果:冠心病组血浆Hcy、TC、TG、LDL-C及sLDL水平明显高于对照组,HDL-C低于对照组,差异有统计学意义(P<0.05),Hcy与sLDL水平随冠状动脉病变支数增加而升高(P<0.05)。sLDL和血浆Hcy水平与冠状动脉病变程度有关,sLDL和血浆Hcy水平呈正相关。结论:sLDL和血浆Hcy水平呈正相关,且与冠心病发病及病变严重程度有关。
Objective：To investigate the relationship between small low-density lipoprotein （sLDL） particles and plasma homocysteine in coronary heart disease （CHD）. Methods：The levels of plasma lipid, small dense LDL percentage of total LDL and homocysteine were measured in 109 patients identified by coronary angiography. The relationship was studied between the level of small dense LDL and homocysteine in different groups. Results： The levels of serum cholesterol （TC）, triglyceride （TG）, LDL-C, small LDL and homocysteine were significantly higher in patients with CHD than those in controls（P 0.05）. The level of HDL-C was lower in patients with CHD than that in controls （P 0.05）. With the number of stenotic vessels increased, the levels of small LDL and homocysteine increased （P 0.05）. Both levels of small LDL and homocysteine might have the positive correlation with the degree of coronary artery stenosis. A positive correlation was found between levels of small LDL and homocysteine. Conclusion： There are positive correlation between levels of small LDL and homocysteine, which might have significant relationships with the degree of coronary artery stenosis.
出处
《天津医药》
CAS
北大核心
2010年第9期774-776,共3页
Tianjin Medical Journal
作者简介
通讯作者E—mail：Qinqin6351@163．com
