摘要
目的分析早期肥胖患儿胆固醇(TC)水平与代谢综合征、动脉粥样硬化的关系。方法选择100例早期肥胖儿童(肥胖组)与80例非肥胖(非肥胖组)儿童,收集所有儿童临床资料,记录胰岛素抵抗指数(HOMA-IR),采用超声测定所有儿童颈动脉中膜层厚度(IMT)、血管舒张功能(FMD)、颈动脉血管顺应性(CAC)、腹膜前脂肪最大厚度(Pmax),总结TC在肥胖儿童代谢紊乱、早期动脉粥样硬化形成过程中的作用。结果1肥胖组体质量指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、Pmax、甘油三酯(TG)、TC、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、超敏C反应蛋白(Hs-CRP)、HOMA-IR、IMT均高于非肥胖组(P<0.05),其脂联素(AD)、FMD、高密度脂蛋白胆固醇(HDL-C)低于非肥胖组(P<0.05);2肥胖组高血压、高胰岛素血症、低HDL-C、高LDL-C、高TG、高TC、内脏脂肪集聚、代谢综合征所占比例均高于非肥胖组(P<0.05);3TC升高组高血压、高胰岛素血症、高LDL-C、低HDL-C、高TG、代谢综合征、内脏脂肪集聚所占比例均高于TC正常组(P<0.05);4TC>5.20mmol/L肥胖儿童患代谢综合征、动脉粥样硬化风险增高。结论 TC上升为肥胖儿童代谢紊乱及动脉粥样硬化的独立危险因素。
Objective To analyze the relationship between cholesterol（TC）level,metabolic syndrome and atherosclerosis in early obese children.Methods One hundred early obese children（obesity group）and 80 nonobese children（non-obesity group）were included in the study.The clinical data of all children were collected.Insulin resistance index（HOMA-IR）was recorded.Ultrasound was used to determine carotid intima media thickness（IMT）,flow-mediated dilation（FMD）,carotid artery compliance（CAC）and preperitoneal fat maximum thickness（Pmax）of all children.The effects of TC on metabolic disorders and formation process of early atherosclerosis in obese children were summarized.Results 1The body mass index（BMI）,waist circumference（WC）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,Pmax,triglyceride（TG）,TC,low density lipoprotein cholesterol（LDL-C）,fasting insulin（FINS）,high sensitivity C-reactive protein（Hs-CRP）,HOMA-IR and IMT of obesity group were higher than those of non-obesity group while adiponectin（AD）,FMD and highdensity lipoprotein cholesterol（HDL-C）were lower than those in the non-obesity group（P 0.05）.2The proportions of hypertension,hyperinsulinemia,low HDL-C,high LDL-C,high TG,high TC,visceral fat accumulation and metabolic syndrome in obesity group were higher than those in non-obesity group（P 0.05）.3The proportions of hypertension,hyperinsulinemia,high LDL-C,low HDL-C,high TG,high TC,metabolic syndrome and visceral fat accumulation in the TC increasing group were higher than those in the normal TC group（P 0.05）.4The risk of metabolic syndrome and atherosclerosis increased in obese children with TC5.20mmol/L.Conclusion TC increase is an independent risk factor for metabolic disorders and atherosclerosis in obese children.
出处
《山西医药杂志》
CAS
2016年第10期1140-1143,共4页
Shanxi Medical Journal
关键词
肥胖症
胆固醇
脂联素
代谢
动脉硬化
Obesity
Cholesterol
Adiponectin
Metabolism
Arteriosclerosis
作者简介
通信作者：吴婕翎
