摘要
以本实验室制备的15个O/W型空白微乳处方及按照文献所得的8个O/W型空白微乳处方共23个处方为样本,比较电导率-含水量曲线法与目测法测定各处方空白微乳成型的临界值,分析目测法确定O/W型微乳成型临界点的缺陷和不足,探讨电导率-含水量曲线法的理论依据和科学意义。结果表明,电导率-含水量曲线法在确定O/W型微乳成型临界点时与目测法具有显著性差异(P<0.001),电导率-含水量曲线法测定值大于目测法测定值。结果证明,目测法存在着缺陷和不足,提示目测法测定的"临界含水量"值可能在双连续相微乳区域,而电导率-含水量曲线法具备理论可行性及科学意义。
This study is to screen 23 blank O/W type microemulsion （ME） samples,that is 15 samples from our laboratory,and 8 samples from literatrue; compare the conductivity-water content curve （CWCC） method and visual method in determining the critical water content during O/W type MEs＇ formation,to analyze the deficiency and the feasibility of visual method and to exploxe scientific meanings of CWCC method in judging the critical water content of O/W type MEs during formation. The results show that there is a significant difference between the theoretical feasible CWCC method and visual method in determining the critical water content （P 0.001）,and the results judged by conductivity is higher than that by eye-based water content. Therefore,this article firmly confirmed the shortcomings of visual method and suggested that the eye-base ＂critical water content＂ may falls into continuous ME stage during O/W MEs＇ formation. Further more,the CWCC method has theoretical feasibility and scientific meanings in determining the critical water content of O/W type MEs during formation.
出处
《药学学报》
CAS
CSCD
北大核心
2010年第8期1052-1056,共5页
Acta Pharmaceutica Sinica
基金
湖南省自然科学基金资助项目(08JJ3053)
关键词
电导率
微乳
临界值
含水量
conductivity
microemulsion
critical value
water content
作者简介
通讯作者Tel：86-731．85292093，E-mail：xiangdaxiong@163．com
