摘要
目的:评价盐酸替扎尼定治疗三叉神经痛的临床疗效及安全性。方法:45例三叉神经痛患者分为替扎尼定组(A组)、卡马西平组(B组)。在治疗前、治疗后第7、14、28天对患者的疼痛频率、疼痛程度进行评定,并观察其总体有效性、耐受性和安全性。结果:替扎尼定组治疗前后比较均有显著差异(P<0.05),替扎尼定组和卡马西平组两组间疗效有显著差异,替扎尼定组的起效时间较卡马西平组慢,但不良反应少,耐受性好。结论:替扎尼定对于三叉神经痛的治疗是一种有效的药物。
Objective ： To assess the clinical efficacy of tizanidine in the treatment of trigeminal neuralgia. Methods： Fourty-five patients with trigeminal neuralgia randomly divided into tizanidine group （n = 22）, carbamazepine group （ n = 23 ） , all patients completed the 4 weeks of treatment. The clinical efficacy were assessed by patients with Visual analogue scale（VAS） before and after treatment, and the efficacy and safety of these drugs were also evaluated. Results： The improvemnet rate of pain after the treatment of tizanidine group was significantly better than those of before the treatment. Conclusion： Tizanidine is an safe and effective drug in the treatment of trigeminal neuralgia.
出处
《中国疼痛医学杂志》
CAS
CSCD
2010年第4期197-199,共3页
Chinese Journal of Pain Medicine
关键词
三叉神经痛
替扎尼定
卡马西平
Trigeminal neuralgia
Tizanidine
Carbamazepine
