摘要
目的:探讨复康片对卡马西平(carbamazepine,CBZ)胃粘膜损伤的预防作用。方法:将48只大鼠随机分为正常对照组、模型对照组、复康片低剂量组、复康片高剂量组共4组,每组12只。实验第90天,处死所有大鼠,取胃组织在光镜下观察胃粘膜病理学变化。结果:与正常对照组比较,模型对照组胃粘膜萎缩、腺体减少、胃粘膜上皮细胞水肿,粘膜下层组织水肿,毛细血管扩张充血,炎细胞浸润,浅表溃疡形成,部分腺体发生肠上皮化生。中药复康片低剂量组表现胃粘膜上皮细胞轻微水肿,偶见浅表溃疡形成,并可见粘膜下层组织轻微水肿,毛细血管扩张充血,粘膜固有层和粘膜下层可见炎细胞浸润。中药复康片高剂量组表现胃粘膜上皮细胞轻微水肿,未见浅表溃疡形成,粘膜下层组织轻微水肿,毛细血管无扩张充血,仅粘膜固有层见少量炎细胞浸润。结果表明高剂量组的效果要好于低剂量组。结论:复康片可预防卡马西平对胃粘膜的损害。
Objective： To discuss precaution of Fukang tablets to gastric mucous membrane impairment with carbamazepin. Methods： 48 rats were randomly divided into four groups as follow： control, model, Fukang tablets low-dose and Fukang tablets high-dose （12 rats every group）. Rats were killed after 90 days, observed the pathology change of gastric mucous membrane by light microscope. Results： The results showed that there were congestion, infiltrating, superficial ulceration and intestinal metaplasia in the model and there were mild changes in the Fukang tablets low-dose and Fukang tabellas high-dose. Conclusion： Fukang tablets have the functions to prevent the gastric mucous membrane lesion by earbamazepine.
出处
《河南中医学院学报》
2007年第1期34-35,共2页
Journal of Henan University of Chinese Medicine
基金
河南省科学技术厅基金资助项目(编号:991170620)
河南省教育厅基金资助项目(编号:1999360018)
关键词
卡马西平
胃粘膜
预防
复康片
Carbamazepine
Gastric mucous membrane
Fukang tablets
作者简介
高爱社（1971-），女，河南滑县人，医学学士，讲师。
