摘要
目的探讨影响富血小板血浆(platelet-rich plasma,PRP)促进骨再生与修复的相关因素。方法查阅国内外近年有关PRP制备、生理机制及其在骨科领域应用的文献,并进行回顾和综合分析。结果 PRP是自体血小板的浓缩体,含有丰富的血小板,是自体生长因子的来源,有研究表明PRP对骨再生与修复具有促进作用,但其生物性能的发挥受到多种因素的影响,如制作工艺、载体、激活方式、使用浓度、个体差异等。结论 PRP中血小板浓度、质量等均会影响研究结果和结论的可靠性,因此需建立高效稳定的PRP制作方法 。
Objective To investigate the factors that affect platelet-rich plasma （PRP） in promoting bone regeneration and repairing. Methods Recent literature was reviewed, concerning the preparations of PRP, physiological mechanism and the latest applications in orthopedic field. Results PRP, the concentrated body of autologous platelet, was rich in platelets and was the source of autologous growth factors. Many studies had shown that PRP played an important role in promoting bone regeneration and repairing. However, a few experimental results contradicted this point. The reason might be that the biological properties of PRP were influenced by various factors, such as workmanship, vector, activation schemes, working concentration, individual difference. Conclusion The concentration and quality of platelet and other related factors of PRP affect the reliability of the results and conclusions. So an efficient and stable production method of PRP should be established.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2010年第8期1004-1008,共5页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
富血小板血浆
影响因素
应用进展
Platelet-rich plasma Impact factor Application development
作者简介
通讯作者：翟文亮，副主任医师，硕士导师，研究方向：骨与关节损伤，E-mail：wlzhai@263．net
