摘要
为研究乳腺浸润性导管癌组织p53表达及腋窝淋巴结转移的相关性，作者利用免疫组化染色检测72例浸润性导管癌标本中p53的表达水平，分析p53表达及腋窝淋巴结转移的关系。得出结果：腋淋巴结转移组共37例（52％），p53阳性表达21例（57％）；未转移组共35例（48％），p53阳性表达11例（31％），转移组p53阳性表达较未转移组明显增高（P〈0．05）；淋巴结转移数1—3个25例（68％）、≥4个12例（32％），p53表达阳性分别是12例（48％）和8例（67％），p53表达阳性率与淋巴结转移数呈正相关（P〈0．05）。结果表明，通过检测乳腺浸润性导管癌组织中p53蛋白的表达水平可以判断腋窝淋巴结转移状况和愈后。
The correlation of p53 expression and axillary lymph node metastasis of breast infiltrating ductal carcinoma was studied by measuring the p53 expression level of the samples of 72 eases of the cancer with immunohistochemical test. The results show that, in the 37 - case group that has axillary lymph node metastasis （ accounting for 52% of the total 72 cases）, there are 21 cases having positive p53 expression （accounting for 57% of the total cases in the group） ; in the 35 -case group that has on axillary lymph node metastasis （accounting for 48% of the total 72 cases）, there are 11 eases having positive p53 positive expression （ accounting for 31% of the total cases in the group） ; the p53 positive expression level of the metastasis group is remarkably higher than that of non -metastasis group （P 〈 0.05 ） ;there are 25 cases （accounting for 68% of the total 72 cases） having 1 to 3 lymph nodes with metastasis; 12 cases （accounting for 32% of the total 72 cases） with more than 4 lymph nodes with metastasis, whose number of having positive p53 expression is 12 （48%） and 8 （67%）, respectively, demonstrating a positive correlation of p53 positive expression and the number of lymph nodes with metastasis （ P 〈 0.05 ）. Therefore, we can judge the axillary lymph node metastasis and make prognosis by testing the p53 expression level of breast infiltrating ductal carcinoma.
出处
《辽东学院学报（自然科学版）》
CAS
2010年第1期31-34,共4页
Journal of Eastern Liaoning University:Natural Science Edition
基金
辽东学院科研基金项目(2008Z05)
关键词
乳腺浸润性导管癌
P53
腋窝淋巴结转移
breast infiltrating ductal carcinoma
p53
axillary lymph node metastasis
作者简介
林黎娟（1968-），女，辽宁丹东人，硕士，副教授，研究方向：医学影像诊断方向。
