摘要
目的:探讨环氧化酶-2(COX-2)和生存素(Survivin)在乳腺良性病变、乳腺导管原位癌及乳腺浸润性导管癌中的表达及其临床意义。方法:应用免疫组化染色法检测乳腺良性病变、乳腺导管原位癌、乳腺浸润性导管癌组织中COX-2和Survivin的表达情况。结果:COX-2在乳腺浸润性导管癌中的阳性表达率为81.67%,明显高于乳腺良性病变(50.00%)和乳腺导管原位癌(76.67%),差异有统计学意义(P<0.05)。Survivin在乳腺浸润性导管癌中阳性表达率为70.00%,明显高于乳腺良性病变(41.67%)和乳腺导管原位癌(60.00%),差异有统计学意义(P<0.05)。COX-2阳性表达与乳腺癌腋窝淋巴结转移、临床分期、雌激素受体(ER)阳性表达有关(P<0.05),而与患者发病年龄、肿瘤大小、孕激素受体(PR)情况、患者是否绝经无关(P>0.05)。Survivin阳性表达与乳腺癌腋窝淋巴结转移及临床分期有关(P<0.05),而与患者年龄、肿瘤大小、ER、PR、患者是否绝经无关(P>0.05)。在乳腺浸润性导管癌中COX-2阳性表达与Survivin阳性表达呈正相关(r=0.33,P<0.05)。结论:COX-2与Survivin在乳腺癌的发生、发展中起重要作用。COX-2与Survivin阳性表达密切相关,在乳腺癌的发生、发展中起协同作用。
Objective： To investigate the relationship between the expression of cyelooxygenase-2 （COX-2） and survivin in breast benign lesion, ductal carcinoma in situ and invasive breast carcinoma and their clinical significances. Methods： Sixty cases of breast benign lesion, 60 cases of ductal carcinoma in situ and 60 cases of in invasive breast carcinoma were detected by of the immunohistochemical staining. Results： The positive rate of COX-2 were 50.00% （30/60） in breast benign lesion, 76.67%（46/60） in breast ductal car- cinoma in situ and 81.67%（49/60） in breast invasive ductal carcinoma, the difference showed statistically significance （P 〈0.05）. In breast benign lesion the positive rate of survivin was 41. 67% （25/60）, in breast ductal carcinoma in situ it was 60.00% （36/60）, in breast invasive ductal carcinoma the positive rate of survivin was 70.00% （42/60）, which were significantly different （P〈0.05）. COX-2 expression was not associated with patient＇s age, tumor size, PR state, menopause or not （P〉0.05）, but it was correlated with patient＇s lymph node metastasis, clinical stages, estrogen receptor positive （P 〈0.05）. Survivin expression was not associated with patient＇s age, tumor size, ER state, PR state, menopause or not （P〉0.05）, but it was correlated with patient＇s lymphnode metastasis, clinical stages （P 〈0.05）. COX-2 expression was positive relation to survivin expression （r = 0.33 ,P 〈0.05）. Conclusion： COX-2 and survivin might play an important role in the carcinogenesis and progression in breast carcinoma. A positive correla- tion between expression of COX-2 and survivin were observed in breast carcinoma,COX-2 has coordinated action with survivin in the carcinogenesis and progression in breast carcinoma.
出处
《新疆医科大学学报》
CAS
2008年第11期1528-1530,1533,共4页
Journal of Xinjiang Medical University
关键词
环氧化酶-2
生存素
乳腺癌
免疫组化
cyclooxygenase-2
survivin
breast carcinoma
immuno-histochemistry
作者简介
艾秀清（1975-），女，住院医师，硕士研究生，研究方向：乳腺肿瘤放射治疗。
