摘要
[目的]探讨肺阳虚大鼠病理模型方法。[方法]采用烟熏(外邪犯肺)、冰水游泳(形寒劳倦)、常温游泳(劳倦)、服用他吧唑冰水溶液(免疫抑制、内饮生冷)多因素复合造模法来制备肺阳虚证大鼠模型。观测大鼠体征,测定血液流变学指标。[结果]造模后期,大鼠出现喘鸣、呼吸急促、畏寒少动、精神萎靡、毛发凌乱无光泽、饮水量下降等症状;模型大鼠体重、背部温度、肛温、抓力呈显著性下降(P<0.05);低切变率下的全血粘度、全血还原粘度、红细胞刚性指数、电泳指数均显著性升高(P<0.05)。[结论]该造模方法能较好的与肺阳虚之临床症状相吻合,表明该方法是可行的。
[Objective]We established a model of Lung-Yang Deficiency.[Methods]The factors such as smoking（exogenous evil effect on lung）,swimming in ice water（cold body and exhaustion）,swimming in common water（exhaustion）,and taking the methimazole ice solution（immune suppression and inhale cold）were adopted to establish this Lung-Yang Deficiency model.SD rats were treated for 35 days,and their physical signs（diet changes,drinking and other typical symptoms）were observed.The hemorheological parameters of the treated animals were measured.[Results]At the later period,rats in the Lung-Yang Deficiency model showed several symptoms,such as wheeze,breathlessness,meanwhile,accompanied with dullness,drinking less water,chill.Compared with the normal group,the body weight and the back temperature of the treated rats were decreased significantly.The whole blood viscosity（WBV）and whole blood reduced viscosity（WBRV）on the low shear rate were significantly increased from the normal.So was found the rigidity finger,deformed finger and electrophoresis finger of RBC parameters.[Conclusion]This model is fit to the clinical investigation of Lung-Yang Deficiency,resulting in that our method for model establishment is feasible.
出处
《浙江中医药大学学报》
CAS
2010年第2期163-165,168,共4页
Journal of Zhejiang Chinese Medical University
基金
国家重点基础研究发展计划(No:973计划
2007CB512603)~~
关键词
肺阳虚
大鼠
血流变
lung-yang deficiency
rats
blood hemorheology
