摘要
目的研究根据指南针原理设计的排尿报警装置所采用的硅胶包埋的永磁铁的生物安全性。方法实验组采用硅胶包埋的直径10mm、厚3mm的钕铁硼永磁铁,其表面磁感应强度为0.30特斯拉;对照组采用同等规格的钕铁硼合金。将植入物植于8只兔子的椎旁肌间隙内,饲养1年,观察兔的反应和局部病理变化。结果肌间植入后,8只兔子切口愈合良好,1只术后19天因纳差消瘦死亡,其它7只耐受性好,1年后对照组和实验组植入物周围组织炎症反应和纤维囊级别均为1级。结论钕铁硼永磁铁经硅胶包埋后具有良好的生物安全性,符合临床使用要求。
Objective To investigate the biological safety of silicon membrane embedded permanent magnets ofa micturition alert device on the principle of compass. Methods The experimental group used a silicon membrane embedded NdFeB magnet which was 10 mm in diameter and 3 mm in thickness with a magnetic induction intensity of 0.3 Tesla at the center of the pole face surface. The control group used a silicon membrane embedded NdFeB alloy with the same dimensions. The grafts were implanted into the spatium intermusculare of the lateral vertebral muscle in 8 rabbits. All the rabbits were scheduled to be fed up to one year. Both the reaction of rabbits and local pathology around the grafts were observed after implantation. Results Wound healing was normal after muscular implantation of gratis in 8 rabbits, one of which died from emaciation 19 days after operation and others lived with excellent tolerance. The grades were 1 for the inflammatory reaction and fibrous capsule of the local tissue around the grafts in both experimental and control group. Conclusion NdFeB permanent magnets embedded with silicon membrane were biologically safe to meet the criteria for clinical application.
出处
《生物骨科材料与临床研究》
CAS
2010年第2期1-4,共4页
Orthopaedic Biomechanics Materials and Clinical Study
基金
国家自然科学基金资助项目(30772217)
关键词
排尿报警装置
磁场
生物安全性
硅胶
Micturition alert device, Magnetic field, Biological safety, Silica gel
作者简介
王剑火（1973-），男，主治医师，博士，研究方向：脊髓损伤后膀胱功能重建。E-mail：xianyou2004@163．com
【通讯作者】侯春林，教授，博士生导师，研究方向：创伤与修复重建、脊髓损伤后膀胱功能重建，E—mail：chunlin_hou@yahoo．com．cn
