摘要
将自行合成的聚丙交酯（ＰＬＡ）棒（４ｍｍ×５ｍｍ×３５ｍｍ）植入１２只兔的背部肌肉内，于术后２、４、６、８、１２、２４周取出，采用不同方法（粘均分子量，机械强度和组织学观察）观察其在体内降解吸收和组织反应。结果表明植入８周后，分子量降解、弯曲和剪切强度维持都是５０％。２４周时，分子量为初始时的３０％，重量保持了８３％，试件外形基本不变。植入早期，ＰＬＡ引起周围组织轻度炎性反应，随后被致密的纤维囊包裹。所有试件均可为组织耐受。
Theselfdesignedpolylactide(PLA)rods(4mm×5mm×35mm)wereimplantedintothedorsalmusclesof12rabbitsforthestudyofinvivotissuereactions.Theanimalsweresacrificedat2,4,6,8,12and24weeksaftersurgery.Viscositymeasurement,mechanicalstrengthassessment,andmicroscopicstudieswereemployedtostudythedegradationoftherodsinvivoandthetissueresponse.TheresultsshowedthatthedegradationofmolecularweightofPLAandtheretentionofmechanicalbendingandshearstrengthwas50%after8weeksofimplantation.By24weeks,themolecularweightofPLAhadretainedonly30%oftheintitialvalue,whereas83%oftheweightstilmaintained.Therewerenoobviouschangeofthecontoursoftherods.Duringtheearlyperiodofimplantation,amildin-flammatoryreactionwasseenoverthesurroundingtissue.Vascularizationofthesampleswasobservedfromthecompactfibroidcapsulesinalthespecimens.Althesampleswereweltoleratedbythesuroundingtisssue.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1996年第10期656-658,共3页
Chinese Journal of Orthopaedics
