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iNKT细胞在系统性红斑狼疮发病机制中的研究进展 被引量：4

Progress on iNKT cell in the pathogenesis of Systemic Lupus Erythematosus
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摘要 iNKT细胞是T细胞的一个亚群，表达T细胞表面受体（TCR）和NK细胞表面标志物NK1．1（人类为CD161），能够被非经典MHC-I类分子CD1d提呈的糖脂抗原所激活，不仅具有T细胞的免疫调节作用，也具有NK细胞的自然杀伤作用。近年来的研究发现iNKT细胞在多种自身免疫性疾病，包括系统性红斑狼疮（Systemic Lupus Erythematosus，SLE）的发生中扮演重要角色，但具体机制还不明确。 Invariant natural killer T cells （iNKT） is a unique T cell lineage, which bearing an invariant T cell veceptcor （TCR） and NK1.1 （human CD161 ） , and can recognize a small variety of glycolipid antigens when CD1d （non-classical MHC-I） presents, iNKT ceils play a regulatory role during immnne responses by producing eytokines, and have the ability to destroy other cells as NK cells. Despite the ambiguous mechanism, recent researches show that iNKT plays an vital role in many autoimmune diseases including systemic lupus erythematosus （SLE）.
作者 汪玫 瞿金涛 周琳
机构地区 中国人民解放军第二军医大学研究生管理大队学员一队 第二军医大学长征医院实验诊断科
出处 《国际免疫学杂志》 CAS 北大核心 2010年第2期85-88,共4页 International Journal of Immunology
关键词 系统性红斑狼疮 INKT细胞 自身免疫 Systemic lupus erythematosus iNKT Autoimmune
分类号 R593.241 [医药卫生—内科学]
作者简介 通信作者：周琳，E-mail：gracelin_zhou@yahoo．com．cn
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参考文献25

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二级参考文献40

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共引文献7

同被引文献19

  • 1张艳,魏海涛,陈元鼎.自然杀伤T细胞的研究进展[J].生物技术通报,2009,25(S1):10-14. 被引量：5
  • 2马莉,楚兰,杨洁,李虹.系统性红斑狼疮患者外周血Vα24-Vβ11自然杀伤T细胞致病性的研究[J].中华检验医学杂志,2005,28(2):181-183. 被引量：3
  • 3冷晓梅,蒋颖,赵岩,唐福林,于孟学.造血干细胞移植治疗类风湿关节炎[J].北京医学,2006,28(1):33-37. 被引量：5
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引证文献4

二级引证文献15

国际免疫学杂志
2010年 第2期

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