摘要
胸腺来源的CD4^＋CD25^＋调节性T细胞（Treg）是机体维持自身免疫耐受的重要组成部分，约占CD4^＋T细胞的5％-10％。它具有免疫抑制及免疫无能的特性，是最重要的Treg细胞的亚群之一。近年发现CD4^＋CD25^＋Treg细胞主要通过分泌一些抑制性细胞因子和抑制自身反应性T细胞的免疫应答等方式在维持自身免疫耐受中扮演着重要的角色，其数量的缺乏或功能紊乱会导致各种自身免疫性疾病的发生。
CD4^＋CD25^＋ regulatory T（Treg）cells, originated frem the thymus and constitute approximately 5% - 10% of CD4^＋ T cells, exert an important function in the maintenance of self immune tolerance. As an important subset of regulatory cells, CD4^＋CD25^＋ Treg cells have the features of hyporesponsive and anergic to antigen stimulation. Recently, many researches have indicated that CD4^＋CD25^＋ Treg cells play an important role in the maintaining the immune tolerance in the autoimmunity mainly by secreting immunosuppressire eytokines such as IL-10 and TGF-β, and suppressing the activation of serf-reactive T cells. Furthermore, their absence or functional deficiency may lead to various autoimmune diseases.
出处
《国际免疫学杂志》
CAS
2007年第1期27-31,共5页
International Journal of Immunology
基金
安徽省临床医学重点学科应用技术项目（05A008）
作者简介
硕士研究生
硕士研究生,通讯作者：李向培。E-mail：lilumu@mail．hf.ah．cn
