摘要
目的:研究运动训练大鼠长期停训后海马神经元特异性烯醇化酶的表达变化。方法:参照Bedford跑台训练方案分别建立雄性SD大鼠有氧训练与疲劳训练模型,停训28周后,应用免疫组织化学技术探讨长期停训对大鼠脑海马组织神经元特异性烯醇化酶(Neuron-Specific enloase,NSE)表达的影响。结果:有氧训练与疲劳训练均抑制大鼠体重的生长,且疲劳训练的抑制作用尤为明显。恢复28周后,体重均不同程度的增加,且疲劳训练大鼠体重增加幅度最大。停训恢复28周后,疲劳训练大鼠海马CA1区NSE的表达明显上调;在海马CA3区,疲劳训练与有氧训练上调NSE的表达不明显。结论:疲劳训练后停训可上调海马神经元特异性烯醇化酶的表达,这可能与疲劳训练使海马CA1区缺氧微损伤相关。
Objective： This paper studies the changes of NSE expression in rats＇ hippocampus after long training interval. Methods： Male SD rats are used to set up model of aerobic training and fatigue training according to Bedford treadmill training plan. All rats live in normal cage for 28 weeks and accept the impact of long training interval on the changes of NSE expression in rats＇ hippocampus by immunohisyo chemistry method. The result shows that aerobic training and fatigue can restrain the increasing of rats＇ weight, it is more obvious in the intensity fatigue. After stopping training for 28 weeks, aerobic training restrains the increasing of rats＇ weights; fatigue training can intensify the increasing of rats＇ weights. After stopping training, fatigue training promotes NSE expression in CA1 area of hippocampus obviously. Conclusions： interval after aerobic training promotes NSE expression may relate to the slight injury in CA1 area of hippocampus caused by fatigue training.
出处
《北京体育大学学报》
CSSCI
北大核心
2009年第11期57-60,共4页
Journal of Beijing Sport University
作者简介
邱宏军，讲师，硕士，研究方向运动人体科学及体育教育学。
