摘要
目的研究补体因子H基因1277T〉C多态性与不稳定型心绞痛发病的相关性。方法运用聚合酶链反应限制片长多态性检测补体因子H 1277T〉C单核苷酸多态性位点基因型,观察其多态性的基因型及等位基因在湖南籍汉族150例不稳定型心绞痛患者和146例健康对照者中的分布频率。结果不稳定型心绞痛组与健康对照组TT、TC基因型和T、C等位基因频率分布差异显著（P〈0.05）,TC＋CC基因型频率分布差异亦有显著性（OR为3.06,95%C I为1.60-5.86,P〈0.01）。结论湖南汉族人群中补体因子H 1277T〉C多态性与不稳定型心绞痛有明显相关性,该基因多态性可能是冠心病遗传易感标志。
[ ABSTRACT] Aim To investigate the association of the complement factor H （ CFH ） 1277T 〉 C polymorphism and unstable angina pectoris （UAP）. Methods Frequency distribution of the genotypes and alleles of 1277T 〉 C single nucleotide polymorphisms （SNP） of CFH were detected by using polymerase chain reaction and restriction fragment length polymorphism （ PCR-RFLP） method in 150 cases with UAP and 146 normal controls of Hunan Han. Results Obvious frequency distribution difference of TT, tic genotypes and T, C alleles in CFH 1277T 〉 C was observed between the UAP and the control groups （P 〈0.05 ）, and the difference of the frequency of the CFH 1227C allele carriers （TC ＋ CC genotypes ） between the two groups was statistically significant （ OR was 3.06, 95 % CI was 1.60 - 5.86, P 〈 0.01 ）. Conclusion It is suggested that CFH 1277T 〉 C SNP is significantly associated with UAP in Hunan Han population.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2009年第12期1024-1026,共3页
Chinese Journal of Arteriosclerosis
关键词
不稳定型心绞痛
补体因子H
基因多态性
Unstable Angina Pectoris
Complement Factor H
Gene Polymorphism
作者简介
袁海军，硕士研究生，研究方向为冠心病防治，E-mail为navy-yuan@qq．com。
袁梅，博士研究生。
通讯作者 曾高峰，博士，副主任医师，硕士研究生导师，E-mail为qichingnudou@tom．com。
