摘要
急性冠脉综合征主要是由于具有易损性的冠状动脉粥样硬化斑块发生破裂或蚀损,继发血栓形成,并引起具有严重危害的急性冠状动脉事件。炎症反应是影响冠状动脉粥样硬化斑块易损性的主要因素,参与反应的炎症因子是近年来研究的热点。有研究发现白细胞介素-18(IL-18)作为一个促炎症因子,会增加斑块的易损性,而白细胞介素-10(IL-10)作为主要的抗炎症因子,则具有抗动脉硬化及稳定粥样斑块的作用。IL-18/IL-10的比值代表了机体促炎性与抗炎性动态平衡的状态,其比值失衡可能是影响斑块易损性的重要因素。近来有研究认为,IL-18/IL-10的比值可作为急性冠脉综合征患者近期冠脉事件的预测因子。文章就近几年来有关IL-10、IL-18及其比值与冠状动脉粥样硬化斑块易损性的研究进展作一综述,以探讨其可能的临床意义。
Acute coronary syndromes often result from rupture or erosion of the vulnerable coronary atherosclerotic plaques with thrombosis, and lead to serious acute coronary events. A major pathogenic factor of the vulnerability in coronary atherosclerosis plaques is inflammation and the inflammatory cytokines involved in response have become a hotspot in recent years. Interleukin-18 （IL-18） as a pro-inflammatory cytokine has been suggested to increase the vulnerability of plaque. Conversely, interleukin-10 （IL-10） as the main anti-inflammatory cytokine seems to have a protective role in atherosclerosis and stabilize plaque.IL-18/IL-10 ratio represents the balance between pro-inflammatory and anti-inflammatory cytokines. The ratio imbalance may be an important factor to affect the vulnerability of plaque. Recent studies show that IL-18/IL-10 ratio may be a predictor of recurrent coronary events in patients with ACS. This paper will review the research progress of interleukin-18, interleukin-10 and interleukin-18/interleukin-10 ratio and the vulnerability in coronary atherosclerosis plaques to search for its possible clinical significance.
出处
《现代生物医学进展》
CAS
2009年第22期4387-4389,共3页
Progress in Modern Biomedicine
基金
国家自然科学基金(30971265)
上海青年科技启明星计划A类(08QA14041)
作者简介
诸晓枫（1986-），女，本科生，E-mail：carrie915@126．com
通讯作者：李红莉，电话：13917916016，E-mail：liivy@yahoo．cn
