摘要
目的:比较川续断超微粉和细粉川续断皂苷Ⅵ的溶出特性。方法:采用HPLC法测定川续断超微粉和细粉中川续断皂苷Ⅵ绝对含量、1h体外溶出量和溶出速率。结果:川续断超微粉和普通粉中川续断皂苷Ⅵ绝对含量分别为4.87%、4.74%,1h后溶出量分别为48.2mg/g、47.5mg/g,溶出速度参数T0.9分别为0.23min、10.41min。结论:川续断超微粉碎并不会影响川续断皂苷Ⅵ的绝对含量和体外溶出量,但可明显提高其溶出速率。
AIM： To compare the dissolution of asperosaponin Ⅵ between the ultra-micro powder and the fine powder of Radix Dipsaci. METHODS ： The real contents, in vitro release and releasing rate of asperosaponin Ⅵ were determined by HPLC for the ultra-micro powder and the fine powder. RESULTS： In the ultramicro powder and the ordinary powder, the real content of asperosaponin Ⅵ were 4.87% , 4.74%, respectively; in vitro release in 1 h were 48.2 mg/g, 47.5 mg/g, respectively; releasing rate parameter T0.9 were 0.23 min, 10.41 min, respectively. CONCLUSION： The ultra- micro porphyrization could not influent the real content and in vitro release of asperosaponin Ⅵ in Radix Dipsaci. But it could improve the releasing rate of asperosaponin Ⅵ.
出处
《中成药》
CAS
CSCD
北大核心
2010年第1期100-102,共3页
Chinese Traditional Patent Medicine
基金
自然科学基金重点项目(30730113)
关键词
川续断
超微粉
普通粉
川续断皂苷Ⅵ
溶出特性
Radix Dipsaci
ultramicro powder
ordinary powder
asperosaponin Ⅵ
dissolution property
作者简介
张春凤（1967-），女，副教授，博士，从事中药制剂和中药炮制研究。
通讯作者：杨中林，教授，博导。Tel：（025）85322508 E-mail：zhangchunfeng67@163．com
