摘要
代谢组学、基因组学、转录组学和蛋白质组学是系统生物学研究的重要组成部分。近年来,在代谢组学领域,微生物代谢组学的研究受到人们的重视,成为研究的热点。本文综述了微生物代谢组学的研究方法,包括样品处理、分析平台、数据处理和生物学解释等,并讨论了微生物代谢组学在代谢工程方面的应用潜力,以及微生物代谢组学的研究前景和所面临的挑战。
In the post-genomic era,metabolomics（or metabonomics）,genomics,transcriptomics and proteomics have become important tools in systems biology.In metabolome analysis field,microbial metabolomics has received much attention in recent years mainly because it supports and complements a wide range of microbial research areas from new drug discovery efforts to metabolic engineering.This review is mainly focused on the current methods and advances in microbial metabolomics,trying to direct the reader to the main approaches for microbial metabolome analysis,reviewing the developments of methodologies in microbial metabolomics.These developments range from sample preparation,analytical platform and data analysis to biological interpretation.Apart from the description of the developments,we will try to discuss the potential of microbial metabolomics in metabolic engineering field,research prospect and challenge of microbial metabolomics in the future.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2010年第1期163-172,共10页
Progress in Chemistry
基金
国家重点基础研究发展计划(973)项目(No.2007CB707802)
国家自然科学基金项目(No.20536040)资助
关键词
微生物代谢组学
系统生物学
数据挖掘
代谢物
代谢工程
microbial metabolomics
systems biology
data mining
metabolite
metabolic engineering
作者简介
Corresponding author e-mail：chentao@tju. edu. cn
