摘要
目的了解铜绿假单胞菌对多种抗菌药物耐药性的动态变迁及感染病例科室分布,为临床治疗铜绿假单胞菌感染提供参考依据。方法采用法国生物梅里埃公司的API鉴定系统及VITEK2系统进行细菌鉴定,用K-B纸片扩散法进行药敏试验,用WHONET5.4软件分析铜绿假单胞菌的耐药性。结果9年来铜绿假单胞菌对12种抗菌药物的耐药率逐年上升,只有美罗培南、亚胺培南、头孢他啶和环丙沙星的耐药率<30%,多药耐药铜绿假单胞菌共有94株,主要分布在重症监护病房、呼吸内科。结论铜绿假单胞菌对多种抗菌药物耐药,且耐药率逐年增加,在治疗时应根据药敏试验合理谨慎使用抗菌药物,以有效控制及延缓耐药株的产生。
OBJECTIVE To study the changes in drug resistance and distribution of Pseudomonas aeruginosa to guide drug treatment in clinic.METHODS P.aeruginosa was identified by API and VITEK2 system,and its antimicrobial ressistance was determined by Kirby-Bauer method.The antimicrobial ressistance rates were analyzed by WHONET 5.4 software.RESULTS The resistance of P.aeruginosa to 12 antibiotics was increased in the past nine years.The resistant rate to meropemem,imipenem,ciprofloxacin and ceftazidime was below 30%.Among 2127 strains of P.aeruginosa,94 strains were identified multi-drug resistant and found more frequently in ICU,and Respiratory Department.CONCLUSIONS P.aeruginosa is resistant to many kinds of antimicrobial agents,and resistant rate is increasing year by year.In order to control and slow down the occurrence of the resistant strains,it should be more careful to choose antimicrobial agents according to the antimicrobial susceptibility test.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第23期3255-3257,共3页
Chinese Journal of Nosocomiology
关键词
铜绿假单胞菌
抗菌药物
耐药性
监测
Pseudomonas aeruginosa
Antibiotics
Drug resistance surv illence
