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动态监测耐亚胺培南铜绿假单胞菌耐药性特征及分析 被引量:1

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摘要 目的:动态监测分析耐亚胺培南铜绿假单胞菌(IRPA)的耐药特征,为临床有效合理使用抗生素提供依据。方法:按常规方法及API20NE系统分离鉴定铜绿假单胞菌,以K-B法检测其药物敏感性,按2005年NCCLS标准判读结果,使用whonet5.3软件进行数据统计处理。结果:IRPA主要分离自痰液标本(66.7%),其次为咽拭子(13.3%)、分泌物(9.2%)、中段尿(4.9%)、脓液(3.1%)和血液(2.8%)等。与亚胺培南敏感铜绿假单胞菌(ISPA)相比,5年间除FOX、CXM、CZO、AMK和SMX等耐药率无明显提高外,差异无统计学意义(P(0.05)。其余抗生素差异均有显著性(P<0.01)。结论:IRPA在临床标本中分布广泛,其耐药性较ISPA更为严重,在限制使用IMP、PIP/TAZ和喹诺酮类药物的同时,应尽可能根据药物敏感试验合理使用抗生素。
作者 杨春云 王磊
机构地区 莱州市人民医院
出处 《实用医技杂志》 2008年第29期4060-4061,共2页 Journal of Practical Medical Techniques
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