摘要
目的回顾性分析紫癜性肾炎（HSPN）的临床特征。方法1998年10月-2008年10月共48例HSPN,分为单纯血尿及（或）尿蛋白〈1g/d组（A）、血尿及尿蛋白〉1g/d组（B）、伴肾功能损害及（或）高血压组（C）、肾病综合征组（D）,对比分析各组临床资料差异。结果HSPN占肾活检例数9.4%,11-30岁占65%,男：女1.8∶1。A组（16.7%）病理以Ⅰ或Ⅱ型、B组（43.8%）以Ⅱ或Ⅲ型、C组（27.1%）以〉Ⅲ型、D组（12.5%）以Ⅱ或Ⅲ型为主。C组62.5%肾小管萎缩、42.9%间质纤维化、62.5%间质炎细胞浸润。伴高血压者87.5%小动脉管壁增厚。总有效率87.5%,病理轻者疗效好。部分患者用来氟米特或霉酚酸酯收到了与环磷酰胺相似的疗效。结论HSPN青壮年男性并不少见,临床表现、病理类型及治疗效果之间存在一定的平行关系。
Objective To analyze the feature of Henoch-Schonlein purpura nephritis （HSPN）. Methods 48 cases of HSPN from Oct. 2003 to Oct. 2008 were divided into 4 groups ： A hematuria and （or） 24h urine protein〈 1 g/d, B hematuria and 24h urine protein〉1g/d,C combined with renal insufficiency and （or）hypertension, D nephrotic syndrome. The clinical data among groups were analyzed and compared. Results HSPN occupied 9.4% of total renal biopsy cases. 65% were 11 - 30 years. Male： female 1.8 ： 1. Group A occupied 16. 7% ,type Ⅰ or Ⅱ in pathology;B 43.8% ,type Ⅱ or Ⅲ;C 27.1% ,type Ⅲ and above;D 12. 5% ,type Ⅱ or Ⅲ In C, there were 62.5% with tubule atrophy,42. 9% with interstitial fibrosis,62. 5% with inflammatory cell infiltration. 87.5% with hypertension presented with thickening of the arteriole wall. The total effective rate is 87.5% ,with better effect in mild patients. Leflunomide or myeophenelie acid had gained comparing result as cyclophosphamide. Conclusion HSPN was common in young adults. There were some extent of parallel relations between clinical presentations, pathological changes, and therapeutic effect.
出处
《四川医学》
CAS
2009年第12期1876-1878,共3页
Sichuan Medical Journal
关键词
紫癜性肾炎
临床表现
病理
疗效
henoch-schonlein purpura nephritis（HSPN）
clinical symptoms
pathology changes
therapeutic effect
