摘要
目的:探讨强直性脊柱炎(AS)患者生存质量的变化及生存质量下降的相关机制。方法:对57例AS患者的生存质量进行测评,内容包括生存质量测定量表简表(WHOQOL-BREF)、疼痛目测类比法(VAS)、Bath强直脊柱炎功能指数(BASFI)、Bath强直脊柱炎疾病活动指数(BASDAI)及整体指数(BAS-G)、症状分级评分、焦虑与抑郁自评量表(SAS、SDS)、流式细胞仪检测调节性T细胞表达频率,并进行相关分析。结果:①57例患者生存质量及其生活环境、生理功能、心理状态、社会关系、自我健康评价各维度平均值均低于正常值,其中45.6%的患者生存质量平均积分<60分;SAS和SDS标准分均高于我国常模,有焦虑、抑郁情绪的患者分别占33.3%、42.1%;血沉、C-反应蛋白均明显高于正常值;调节性T细胞表达频率低于正常值。②AS患者生存质量及各维度平均积分与SAS和SDS标准分、BASDAI、BAS-G、BASFI、症状总积分及VAS评分呈负相关。结论:AS患者的生存质量严重下降,部分患者出现焦虑抑郁情绪,以抑郁为主;AS与症状体征、病程、疾病活动、情绪等密切相关,其调节性T细胞的表达频率低于正常值;提示AS的疾病活动及调节性T细胞的表达频率的降低是生存质量下降的主要机制。
Objective：To investigate and analyze the quality of life of patients with ankylosing spondylitis （AS）, and the related mechanism of the worsened quality of life. Methods： Fifty-seven patients with AS were selected to evalu ate and analyze the condition of life quality. The scale was made by following methods, such as The World Health Organi- zation quality of life questionnaire （WHOQOL-BREF）, visual analog scale （VAS）, Bath ankylosing spondylitis functional index （BASFI）, Bath ankylosing spondylitis disease active index （BASDAI）, Bath ankylosing spondylitis global index （BANG）, the main symptoms and signs integral, selbreported anxiety scale （SAS）, self reported depression scale （SDS）, and CD4＋CD25＋CD127lo regulatory T cells （Treg） were analyzed using flow cytometry. Results： （1） Among the 57 patients with AS, the average percentage of life quality including aspects of life surroundings, physical function, psychological function, social function and health perceptual ability was obviously reduced. There were 45.5% patients whose average score was less than 60. Standard scores of SAS and SDS were all significantly higher than those of health adults. The incidence of anxious and depressive symptom was 33.3% and 42.1% respectively. Both CRP and ESR were higher than those of health adults. Treg percentage of patients was （3.46±1.06） G, which was lower than that of health adults. （2） The quality of life and the average scores of all aspects were negatively correlated to the level of BASDSDAI, BAS-G, BASFI, symptoms scores, VAS and other indicators of disease activity. Conclusion：The level of the life quality of AS patients is seriously reduced. Some of them have anxious and depressive symptoms, in which depressive symptoms are major. The worsened quality of life is closely correlated to the signs, symptoms, disease course, disease activity and the mood. Treg percentage of these patients is lower than that of health adults. It is suggested that the disease activity and the reduced Treg are the main mechanism of the worsened life quality.
出处
《中国康复》
2009年第6期390-392,共3页
Chinese Journal of Rehabilitation
关键词
强直性脊柱炎
生存质量
相关分析
ankylosing spondylitis
quality of life
correlations
作者简介
刘健（1964-），男，教授，主任医师，博士研究生导师，主要从事中医药防治风湿病的研究。
