摘要
目的研究尿激酶型纤溶酶原激活物受体(uPAR)在下咽癌组织中的表达及其临床意义。方法应用免疫组织化学SABC法检测下咽癌患者50例(A组)和对照组10例(B组)uPAR蛋白表达,分析其与下咽癌临床病理参数及颈淋巴结转移的关系。结果A组uPAR表达阳性率68%,明显高于B组的10%(P<0.01)。uPAR的表达与病理分级、淋巴结转移相关(P<0.01),而与临床分期、年龄、性别无关(P>0.05)。结论uPAR蛋白在下咽癌中阳性表达明显上调,且与病理分级、淋巴结转移相关,可作为下咽癌诊断和预后的参考指标之一。
Objective To investigate the expression and significance of urokinase-type plasminogen activator receptor （uPAR） in hypopharyngeal carcinoma. Methods Samples of 50 hypopharyngeal carcinoma（group A） and 10 normal hypopharyngeal tissues（group B） were examined by strep avidin-biotin complex （SABC） immunohistochemical technique for expression of uPAR, relationship of which with pathological grading, lymph node metastasis was evaluated. Results The positive rate of uPAR expression was significantly higher in group A than that in group B（68% vs. 10%） （P〈0. 01）. uPAR positive expression was closely correlated with pathological grading, lymph node metastasis （P〈0. 01）, but not with age, sex and staging. Conclusion The uPAR expression is up-regulated in hypopharyngeal carcinoma tissues, which is correlated with pathological grading and lymph node metastasis and can be a marker for the diagnosis and prognosis prediction of hypopharyngeal carcinoma.
出处
《江苏医药》
CAS
CSCD
北大核心
2009年第12期1423-1425,共3页
Jiangsu Medical Journal
关键词
尿激酶型纤溶酶原激活物受体
下咽癌
Urokinase-type plasminogen activator receptors Hypopharyngeal carcinoma
