摘要
目的:评价布洛伪麻那敏片治疗由普通感冒或感冒所致的上呼吸道症状的有效性和安全性。方法:采用多中心、随机双盲、阳性药物平行对照研究。共完成的病例数为226例。其中A组112例,B组114例,分别予以布洛伪麻那敏片和氨酚伪麻那敏片治疗,药物用法为每日3次,每次1片,疗程3～5d。结果:A组的总有效率为100.00%,总显效率为98.21%;B组的总有效率为99.12%,总显效率为97.37%。表明A组和B组总疗效差异无统计学意义(P>0.05)。两组总有效率和总显效率非劣效性检验显示,A组非劣效于B组(P<0.05)。不良反应发生率,A组和B组分别为20.18%和24.79%(P>0.05)。结论:布洛伪麻那敏片和氨酚伪麻那敏片均系对症治疗感冒所致上呼吸道症状的安全有效药物。
AIM：To evaluate the efficacy and safety of ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets for the treatment of upper respiratory tract infection. METHODS：A multicenter,double-blind,randomizde controlled and positive drug parallel trial was conducted. 226 patients were enrolled and divided into two groups. Group A （112 cases） were treated with ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets and Group B （114 cases）were treated with paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets. The method to take the medicine was one tablet three times a day for 3-5d. RESULTS：The total efficacy rate of Group A was 100%,with the total obvious effective rate of 98.21%; while the efficacy rate and the total obvious effective rate of Group B were 99.12% and 97.37% respectively. The results indicate that the difference between the efficacy rates of the 2 groups had no statistical significance （P〉0.05）. The occurrence rate of the adverse reaction in Group A and Group B was 20.18% and 24.79% respectively （P〉0.05）. CONCLUSION：Both ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets and paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets are safe and effective medicine in the treatment of upper respiratory symptoms caused by cold.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第8期928-932,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
布洛伪麻那敏片
氨酚伪麻那敏片
感冒
ibuprofen pseudoephedrine hydrochloride and chlorpheniramine Maleate tablets paracetamol pseudoephedrine hydrochloride and chlorphenamine maleate tablets cold
作者简介
薛成，男，本科，主治医师，研究方向：危重病救治。Tel：0553—5739229E—mail：qinxue620@sohu．com
