摘要
为探讨补肾壮骨中药治疗去势雌性大鼠所致骨质疏松症的疗效，应用细胞形态立体计量学测试方法测试实验大鼠股骨上段成骨和破骨细胞体密度及数密度的变化。结果表明，（去势＋中药）组成骨细胞体密度、数密度较去势组上升（Ｐ＜０．０５），接近于假手术组；（去势＋中药）组破骨细胞体密度、数密度较去势组下降（Ｐ＜０．０５），接近于假手术组。提示，补肾壮骨中药不但能抑制骨吸收，而且还具有增加骨组织形成的作用，从而有利于骨质疏松症的预防和治疗。
To explore the effect of kidney_reinforcing and bone_strengthening Chinese herbal medicine on osteoporosis in ovariectomized rats, cell morphonetrey was used to measure the volume density (VD) and numerical density (ND) of osteoblast and osteoclast in the upper segment of femur. Thirty_two rats were allocated to four groups: Group I(treated with imitative ovariectomy), Group Ⅱ(treated with ovariectomy),Group Ⅲ(treated with ovariectomy and Chinese herbal medicine) and Group Ⅳ(treated with ovariectomy and western medicine). The results showed that VD and ND of osteoblast markedly increased and those of osteoclast decreased in Group Ⅲ (P< 0.05 ) as compared with Group Ⅳ.It is indicated that the mechanism of kidney_reinforcing and bone_strengthening Chinese herbal medicine for osteoporosis is related to the inhibition of bone absorption and improvement of osteosis.
出处
《广州中医药大学学报》
CAS
1998年第4期281-283,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药管理局科研课题
关键词
骨质疏松
补肾药
成骨细胞
破骨细胞
中医药疗法
OSTEOPOROSIS/TCD therapy
KIDNEY_REINFORCING DRUGS/ther. use
OSTEOBLASTS/drug eff.
OSTEOCLASTS/drug eff.
