摘要
目的探讨伽玛刀治疗脑转移瘤的临床疗效。方法169例脑转移瘤采用伽玛刀治疗，肿瘤周边剂量10-22Gy，平均15.6Gy；中心最大剂量20-46.7Gy，平均34.6Gy。对169例患者伽玛刀治疗后进行临床随访，其中120例患者定期行CT或MRI复查，随访时间为3-43个月。结果影像随访120例中，完全缓解17例（14.2％），部分缓解58例（48.3％），无变化35例（29.2％），恶化10例（8.3％）；肿瘤局部控制率为91.7％（110／120）。临床随访169例，临床症状控制率为87.0％（147／169），平均生存期9.8个月，存活〉6个月108例（63.9％）。结论伽玛刀治疗脑转移瘤疗效好，安全，能有效提高患者生活质量，延长生存期。
Objective To observe the therapeutic effect of gamma knife（GK） radiosurgery on brain metastases. Methods 169 cases of brain metastases were treated with GK. The doses for the tumor margin and center were respectively 10 to 22 Gy（mean 15.6 Gy） and 20 to 46.7 Gy （mean 34.6 Gy）. All patients were followed up after GK radiosurgery periodically,among whom 120 cases were examined with CT or MRI. The follow up lasted for a period ranging from 3 to 43 months. Results Of the 120 cases of brain metastases who were followed up with CT or MRI ex- amination,tumor size vanished in 17 cases（14.2%） ,decreased in 58 cases（48.3%） ,unchanged in 35 cases（29.2%）,increased in 10 cases（8.3%）,local tumor control rate was 91.7%（110/120）. In all the 169 cases,the clinical control rate was 87.0%（147/169） ,the mean survival period was 9.8 months,and more-than-6-month survival rate was 108（63.9%）. Conclusion GK radiosurgery is an safe and effective therapeutic method for brain metastases, and it can promote patient＇s life quality and elongate survival span.
出处
《江西医学院学报》
CAS
2009年第8期45-47,共3页
Acta Academiae Medicinae Jiangxi
关键词
脑转移瘤
伽玛刀
疗效
brain metastases
gamma knife
curative effeet
作者简介
赵令武（1967-），男，硕士，副教授，副主任医师，主要从事影像诊断与伽玛刀放射外科治疗的研究。
