摘要
目的:观察舒芬太尼用于脊柱外科术后自控静脉镇痛(PCIA)中镇痛、镇静效果及安全性。方法:60例脊柱外科手术患者随机分为芬太尼组与舒芬太尼组,均采用全身麻醉,术毕患者清醒后拔除气管导管且行PCIA。记录24h内疼痛视觉模拟评分法(VAS)评分、疼痛描述四分法(VRS)评分、镇静评分法(Ramsay)评分及不良反应。结果:舒芬太尼组获得有效镇痛效果,VAS评分明显低于芬太尼组,VRS评分则高于芬太尼组(P<0.05),其中芬太尼组有5例不能取得完善镇痛效果;舒芬太尼组各时间点Ramsay评分均明显高于芬太尼组(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论:在脊柱外科手术中应用舒芬太尼行PCIA,能够达到良好的术后镇痛、镇静目的,不良反应少,用于患者PCIA安全、有效。
OBJECTIVE： To evaluate the pain - relieving and sedative efficacy and safety of sufentanil in patient - controlled intravenous analgesia after spinal column surgery. METHODS： 60 patients undergoing selective spinal column surgery were randomized to either fentanyl group or sufentanil group. General anesthesia was performed for all the 60 cases, with tracheal catheter withdrawn and patient- controlled intravenous analgesia（PCIA） performed after completion of surgery when patients had regained consciousness. The analgesic efficacy within 24 hours was evaluated using visual analogue score（VAS）, VRS score, Ramsay score and the adverse effects were recorded. RESULTS： In sufentanil group, effective analgesic efficacy was obtained, and the VAS score was significantly lower but the VRS score was significantly higher than in fentanyl group（P 〈 0.05）. Analgesic failure was noted in 5 cases in fentanyl group, and in this group, Ramsay scores at different time points were significantly higher than in fentanyl group（P〈 0.05） . The differences in the incidence of adverse drug reactions between the two groups were not statistically significant（P 〉0.05）. CONCLUSION： Sufentanil is proved to be safe and effective with reliable analgesic and sedative efficacy but fewer side effects for PCIA patients.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第32期2525-2526,共2页
China Pharmacy
关键词
芬太尼
舒芬太尼
镇痛
患者自控静脉镇痛
Fentanyl
Sufentanil
Analgesia
Patient - controlled intravenous analgesia
作者简介
副主任医师。研究方向：临床麻醉。电话：0510—86703368
