摘要
目的:观察舒芬太尼(Sufentanil,简称SF)用于术后患者静脉自控镇痛的镇痛强度、镇静效果、副作用。方法:40例ASAⅠ～Ⅱ级择期行胸部手术患者,随机分为两组,舒芬太尼(SF)组和芬太尼(F)组,术后使用一次性微量止痛泵。药物配方:SF组为舒芬太尼200μg+生理盐水至100ml;F组为芬太尼2mg+生理盐水至100ml。持续流量1.0ml/h,自控剂量(SCA)1.0ml/15min。结果:两组患者对镇痛效果的总满意度(优良率)均在90%以上(P>0.05);镇痛评分(VAS)SF组各时段均低于F组,其中静息状态下疼痛评分(R-VAS)除术后4h外其它各时段均有显著性差异(P<0.05),活动状态下疼痛评分(M-VAS)在术后8、12、48、72h明显低于F组(P<0.05);镇静评分(SS)SF组各时段均高于F组,其中在术后4、8、12、24h有显著性差异(P<0.05)。不良反应两组发生率相似。结论:舒芬太尼用于胸部手术患者术后静脉自控镇痛效果确切,镇静作用强,呼吸抑制轻,恶心、呕吐发生率低,与芬太尼的镇痛效价比相当,甚至略大于1:10,是一种较为理想的术后镇痛药。
Objective: To assess the analgesic and ataractic efficacy and the side effect of sufentanil for postoperative self-controlled infusion analgesia (PSCIA) in the patient with thoracic surgery. Methods: A total of 40 patients (ASAⅠ~Ⅱ) with selective thoracic surgery were equally randomized to receive 100ml of the analgesic regiments containing either sufentanil 200ug (group SF, n=20) or fentanyl 2mg (group F, n=20) for 72 hours. The postoperative self-controlled infusion analgesia was performed with the basal infusion rate of 1.0ml/h, bolus 1.0ml and locking time 15 minutes. Results:There was a satisfactory analgesia rate in each group, the analgesic result in more than 90 percent of patients was very good or good (P>0.05). But group SF got significantly lower pain-relief scores (VAS) in both resting and moving states at 8, 12, 24, 48, 72 h compared to group F (P<0.05). There was no significant difference between the groups in VAS at 4 h after surgery (P>0.05). Significantly higher SS scores were observed in group SF than in group F. No statistical difference was observed in the adverse reactions between two groups. Conclusion: PSCIA with sufentanil in thoracic surgery can achieve satisfactory analgesia and suitable sedation without more incidence of adverse reactions, such as dyspnea, nausea, vomiting. It seems that the analgesic potency of sufentanil is tenfold as strong as that of fentanyl, or even stronger.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2005年第13期767-769,共3页
Chinese Journal of Clinical Oncology
关键词
舒芬太尼
静脉自控镇痛
胸部手术
Sufentanil Patient-controlled infusion analgesia Thoracic surgery
