摘要
目的探讨依那普利联合小剂量氢氯噻嗪治疗高血压患者的临床疗效。方法120例高血压患者随机分为小剂量氢氯噻嗪组(40例)、依那普利组(40例)、氢氯噻嗪联合依那普利组(40例),疗程4周,比较3组治疗前后降压疗效及达标率。结果3组血压下降显著(P<0.05),氢氯噻嗪组与依那普利组血压下降比较差异无显著性(P>0.05),联合用药组较单独用药组血压下降更显著(P<0.05)。联合用药组降压有效率75.00%,达标率72.50%,分别与单独用药组比较P<0.05。结论小剂量氢氯噻嗪和依那普利单用或联用治疗原发性高血压有效,但两药联用显著提高降压疗效及达标率,联用不良反应减少。
Objective To investigate the clinical effect of low dose hydrochlorothiazide and enalapril alone or combination of both in the treatment of essential hypertension. Methods One hundred twenty patients with essential hypertension were randomly divided into low dose hydrochlorothiazide group （40 cases） , enalapril group （40 cases） and hydrochlorothiazide and enalapril group （ 40 cases） , and treated with the appropriate drugs for 4 weeks. The condition of decreased blood pressure before and after treatment, antihypertensive effect and standard reaching rate were compared among the three groups. Results After treatment, blood pressure decreased significantly among the three groups （P 〈 0.05 ） , there was no obvious difference in decreasing the blood pressure between the hydrochlorothiazide group and enalapril group （P 〉 0. 05 ） , but the antihypertensive effect in the drug combination of both was more significant compared with that in two drugs used alone （P 〈 0. 05 ） . The effective rate of depressurization in the hydrocborothiazide and enalapril group was 75.00% and its standard - reaching rate was 72. 50% , and had significant difference from those in the single administration group （P 〈 0.05 ）. Conclusion Low dose hydrochlorothiazide and enalapril alone or combination of both in essential hypertension is effective, the drug combination of both can significantly improve the antihypertensive effect and standard -reaching rate, with less adverse reaction.
出处
《医药论坛杂志》
2009年第18期4-6,共3页
Journal of Medical Forum
关键词
氢氯噻嗪
依那普利
高血压
疗效
Hydrochlorothiazide
Enalapril
Essential hypertension
Curative effect
