摘要
目的观察阿托伐他汀联合疏血通对难治性肾病的治疗作用。方法将患者随机分为对照组和治疗组：在常规应用激素等对症治疗的同时，治疗组加用阿托伐他汀10～20mg／d，疏血通8ml／d，平均治疗5周，观察两组治疗前后血浆凝血酶原时间（町）、国际化标准值（INR）、纤维蛋白原（FIB）、凝血酶时间（TT）、部分凝血酶时间（APTT）、血浆D-二聚体（D—D）、血肌酐（Ser）、甘油三酯（TG）、总胆固醇（CHOL）、24h尿蛋白定量（UAER）等各项指标的变化：结果治疗组治疗后TG、CHOL、D—D及APTT低于治疗前（P〈0．05或P〈0．01）；治疗前后治疗组UAER及血肌酐下降较对照组明显（P〈0．05或P〈0．01）。结论阿托伐他汀联合疏血通能有效地改善难治性肾病的高凝状态，减少尿蛋白，延缓肾脏病变的进展．
Objective To observe the therapeutical effect of atorvastatin and shuxue - tong on refractory nephritic syndrome. Methods The patients were randomly divided into treatment group and control group. Besides the roution medicine,the treatment group were treated with atorvastatin 10-20 mg/d,and injected shuxue- tong 8 ml everyday for five weeks. The variance of PT, INR,FIB,TT,APTT,D - D,serum crestinine,TG,CHOL and UAER were analyzed. Results The contents of TG,CHOL,D - D and APTT level in the treatment group were lower after treatment （ P 〈 0.05 or P 〈 0.01 ） ; the variance of UAER and serum crestinine in the treatment group were obviously lower than that in the control group（ P 〈 0. 05 or P 〈 0.01 ）. Conclusion Atorvastatin and shu xue - tong have significantly effects on improving the hypercoagulabale state, decreasing proteinuria and delaying the depravation of renal lesions.
出处
《临床医学》
CAS
2009年第9期5-7,共3页
Clinical Medicine
关键词
阿托伐他汀
疏血通
难治性肾病
Atorvastatin
Shuxue - tong
Refractory nephritic syndrome
