摘要
目的分析雾化吸入普米克令舒-博利康尼对慢性阻塞性肺病(COPD)急性加重期患者肺功能的影响。方法选择COPD急性加重期患者共60例,治疗前根据肺功能损害严重程度分为A组(FEV1≥50%)和B组(FEV1<50%),每组患者30例。在给予常规治疗的同时,均采用普米克令舒-博利康尼雾化吸入给药,测定两组治疗前及治疗后第5天肺功能,分析两组患者肺功能指标的变化。结果治疗后两组患者肺功能指标中的FEV1、FEV1/FVC、PEF均有好转(P<0.05)。而MMEF、FEF75%两项指标在A组改变不明显(P>0.05),在B组有明显改善,差异有统计学意义(P<0.05)。结论COPD急性加重期雾化吸入普米克令舒-博利康尼能有利于改善肺通气功能。对于重度COPD(FEV1<50%)的患者更能有效地舒张小气道,及早控制气道炎症反应。
Objective To analyze the effects of the inhalation of pulmicorl respules-terbutaline on pulmonary function in patients wilh acute exacerbation of chronic obstructive pulmonary disease （COPD）. Methods Sixty COPD patients with acute ex- acerbation of COPD were cboiced. According to the degree of pulmary function before treatment, the patients were divided into group A（FEV1 I〉50% ）and group B （FEV1 〈50% ）. While all received routine treatment,the patients were given inhalation of pulmicort respules and terbutaline. All patients underwent pulmonary function before treatment and the 5th-day after therapy. Data were statistically analyzed by SPSS windows 12. 0 software. Results The changes of FEVI ,FEV,/FVC,PEF after treatment were greater improved in both groups （P〈0. 05 ）. Compare of changes of MMEF ,FEF75% before and after treatment, the efficient rate were significantly superior in group B than in group A. Conclusion Inhalation pulmieort respules-terbutaline can both improve pulmonary function in COPD patients with acute exacerbation. It is more effective to enlarge small airway and shows a synergistic effect on early airway inflammation control in more severe degree of pulmonary function.
出处
《四川医学》
CAS
2009年第8期1220-1222,共3页
Sichuan Medical Journal
关键词
慢性阻塞性肺病
急性加重
肺功能
雾化吸入
普米克令舒-博利康尼
chronic obstructive pulmonary disease
acute exacerbation
pulmicort respules-terbutaline
inhalation
pulmonary function
