摘要
[目的]观察普米克令舒雾化吸入与静脉用甲基强的松龙治疗慢性喘息型支气管急性发作的临床疗效的不良反应。[方法]慢性喘息性支气管炎急性发作患者60例随机分为治疗组与对照组,治疗组雾化吸入普米克令舒,对照组静脉滴注甲基强的松龙,两组均给予吸氧、抗感染、祛痰,维持水、电解质平衡及万托林氧雾化吸入,治疗前后1周进行临床疗效、血气分析及不良反应评定。[结果]氧雾化吸入普米克令舒与静脉滴注甲基强的松龙均能显著改善临床症状,两组疗效差异无统计学意义(P﹥0.5),两组血气分析治疗后均有明显改善,两组比较差异无统计学意义(P﹥0.5),两组不良反应发生率治疗组明显少于对照组,差异有统计学意义(P﹤0.025)。[结论]普米克令舒氧雾化吸入与静脉滴注甲基强的松龙均能明显缓解病情,但普米克令舒氧雾化在治疗中更具安全性。
[Objective]To observe the clinical adverse effect of breathing in atomization Pulmicort and intravenous injeering of methylprednisolone in treatment of acute episode patients with chronic asthmatic bronchitis. [ Methods] 60 acute episode patients with chronic asthmatic bronchitis were randondy divided into experiment group and control group. The experi-ment group were performed to breath in atomization Pulmicort, and the control group were conducted with intravenous injecting of methylprednisolone. Patients in control and experiment groups were treated with breathing in oxygen, anti-infection, elimi-nating phlegm, keeping water-electrolyte balance and breathing in atomization salbutamol for a week, the clinical therapeutic effect, blood gas analysis and adverse effect before and after treatment were evaluated. [ Results ] The clinical symptoms could be obviously improved after breathing in atomization Pulmicort and intravenous injecting of methylprednisolone, the therapeutic effect in two group had no found significant difference （P〉 0.5）, and the results of blood gas analysis in two groups were obvi-ously improved after treatment, but no significant differences were found between the two groups （P 〉 0.5）. The ineldenee of adverse effect in experiment group was significantly lower than that in control group （P 〈 0.025）. [Conclusion] Breathing in atomization Pulmieort and intravenous injecting of methylprednisolone could significantly relieve the status of acute episode patients with chronic asthmatic bronchitis, but breathing in atomization Pulmicort is more safe in clinical therapy.
出处
《现代预防医学》
CAS
北大核心
2008年第9期1754-1755,共2页
Modern Preventive Medicine
作者简介
王莹（1963-）女，副主任医师，研究方向：慢性阻塞性肺疾病。
通讯作者：余阗，副主任医师，研究方向：支气管哮喘；E-mail：tang.ap@tom.com
