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他汀类药物对动脉粥样硬化抗炎作用机制的新进展 被引量：13

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摘要 动脉粥样硬化是一种慢性炎症性疾病,他汀类药物的多效作用包括抗炎作用,其对动脉粥样硬化的抗炎作用机制包括减少和抑制黏附分子及其功能、阻断CD40-CD40L相互之间的作用及新近发现的抑制Toll样受体的形成、下调转录因子的信号传导等多种机制。
作者 黎东华 李浪
机构地区 广西医科大学第一附属医院心内科
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2009年第5期417-420,共4页 Chinese Journal of Arteriosclerosis
基金 广西医疗卫生重点课题(重200826)
关键词 他汀类药物 动脉粥样硬化 炎症
分类号 R363 [医药卫生—病理学]
作者简介 黎东华，硕士研究生，研究方向为冠心病介入治疗及其防治的研究，E-mail为lidonghua5@tom．com。 李浪，博士，主任医师，教授，博士研究生导师，研究方向为冠心病介入治疗及其防治的研究，E-mail为drlilang@163．com。
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参考文献30

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二级参考文献18

  • 1许文平,邱健,丁力.腹主动脉瘤发病机制及内科治疗进展[J].实用医学杂志,2006,22(9):1086-1088. 被引量：7
  • 2董少红,温隽珉,罗林杰,陈科奇,梁新剑,李宜富,刘华东,陈焕展,黄志昕.大剂量阿托伐他汀对急性冠状动脉综合征的调脂及抗炎作用[J].中国动脉硬化杂志,2006,14(7):613-616. 被引量：15
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  • 7Chase A J, Bond M, Crook MF, Newhy AC. Role of NF-κB activation in metalloproteinase-1, -3 and -9 secretion by human macrophages in vitro and rabbit foarn cells produced in vivo[J]. Arterioscler Thromb Vasc Biol,2002, 22 (5) : 765.
  • 8Nakashima H, Aoki M, Miyake T, Kawasaki T. Iwai M, Jo N, et al. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor-κB and ets transcription factors[J]. Circulation, 2004, 109 (1): 132-138
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共引文献13

同被引文献121

引证文献13

二级引证文献139

中国动脉硬化杂志
2009年 第5期

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