摘要
Tumor stroma interaction in the primary tumor and at distant sites is the emphasis of our research program. In this presentation, I will discuss our recent discoveries: 1) β2-Microglobulin (β2-M), a novel growth factor
Tumor stroma interaction in the primary tumor and at distant sites is the emphasis of our research program. In this presentation, I will discuss our recent discoveries： 1） β2-Microglobulin （β2-M）, a novel growth factor and pleiotropic signaling molecule regulating prostate cancer cell growth, survival, angiogenesis and metastasis; 2） β2-M-induced prostate cancer growthand signaling can be blocked by anti-β2-M antibody and β2-M siRNA; 3） a new proposed mechanism underlying β2-M downstream signaling; and 4） co-targeting strategies for prostate cancer growth, invasion and metastasis.
出处
《中国肺癌杂志》
CAS
2009年第6期I0024-I0024,共1页
Chinese Journal of Lung Cancer
作者简介
Leland W. K. Chung, PhD, professor and director of Emory＇s Molecular Urology and Therapeutics Program, in the Department of Urology, leads the research program that fosters molecular understanding of the urologic disease process and therapeutic targeting of advanced urologic cancers and the educational program for the training of the next generation of the urologic scientists. He heads one of five areas of research emphasis -- mechanisms of tumor-stroma interaction, designated by National Cancer Institute （NCI） as the area with extraordinary opportunity. Dr. Chung is an expert in prostate cancer bioloty and therapy with more than 300 publications in this area of research. Education BS, National Taiwan University, 1962, Agricultural Chemistry MS, Oregon State University, 1965, Biochemistry PhD, University of Oregon Medical School, 1969, Pharmacology Areas of Expertise include： Prostate cancer Bone metastases Cell signaling Molecular imaging Molecular therapy Dr. Chung has been an international leader in the area of tumor microenvironment interactions and specifically the molecular mechanism of prostate cancer and bone stroma interactions. He has served in numerous NCI external leadership roles. Research Interests Dr. Chung serves as the lead investigator for delineating tumor-microenvironment interaction with particular emphasis on stromal-epithelial interac- tion and the roles of soluble factors and insoluble extracellular matrix （ECM） signaling that affects epithelial to mesenchymal transition and tumor growth, migration invasion and metastasis. He and his colleagues focused their studies on characterizing cell signaling network in prostate cancer cells leading to their metastatic behaviors. They have developed numerous human prostate cancer metastatic models that recapitulate clinical progression and have contributed to the understanding of androgen-independent growth and bone metastasis of prostate cancer. The highlights of their research are： Co-targeting tumor and stroma with genetic and drug therapy. Molecular signaling regulating osteomimicry and co-evolution of prostate cancer and stroma Near-infrared imaging and targeting of cancer metastasis. Molecular understanding of redox signaling and radiation resistance. 3-D growth of cancer stem cells and tissue engineering.
