摘要
目的研究Ki-67和增殖细胞核抗原(PCNA)在银屑病和扁平苔藓皮损处表达的一致性。方法应用免疫组化法检测扁平苔藓和银屑病患者皮损处Ki-67及PCNA表达。结果Ki-67在扁平苔藓和银屑病皮损处呈阳性表达,PCNA在扁平苔藓和银屑病皮损处呈强阳性表达,PCNA阳性细胞百分率较Ki-67高(P<0.001),两者在银屑病和扁平苔藓皮损处表达的一致性较差(k=0.08)。结论Ki-67和PCNA在银屑病和扁平苔藓皮损处表达一致性差,可能Ki-67比PCNA更具有特异性。
Objective To investigate the expression of Ki-67 and proliferating cell nuclear antigen （PCNA） protein in the lesions of patients with lichen planus and psoriasis. Methods Immunohistoehemical technique was employed to detect the expression of Ki-67 and PCNA. Results Ki-67 were stained in the leisions of patients with lichen planus and psoriasis, while PCNA were significantly stained. PCNA was stronger than Ki-67 expressed in lesions（P〈0.001）. The consistence of Ki- 67 and PCNA protein expressed was poor in the lesions of patients with lichen planus and psoriasis （k=0.08）. Conclusion The expression of Ki-67 and PCNA protein were unconsistent in the lesions of patients with lichen planus and psoriasis. Ki- 67 might be more superfine than PCNA.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2009年第3期136-138,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
