摘要
目的:探讨急性肺损伤患者血清中肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、血小板激活因子(Platelet activating factor,PAF)及白细胞介素-10(Interleukin-10,IL-10)的变化及意义。方法:采用ELISA方法检测临床上30例急性肺损伤患者血清中TNF-α、PAF、IL-10不同时间段的浓度变化并进行相关性分析。结果:肺损伤患者血清中TNF-α、PAF、IL-10的水平明显高于对照组。结论:血清TNF-α、PAF、IL-10在肺损伤中起着重要作用。提示这3种指标对肺损伤的诊断、治疗及预后有潜在的应用价值。
Objective： To probe the changes of serum and clinical implications of TNF-α（tumor necrosis factors-α） of sera inflammatory cell factors and Interleukin-10（IL-10）, PAF in patients with acute lung injury.Methods ： The dynamic variations of serum of TNF-α, IL-10, and PAF were tested through ELISA method in 30 strictly chosen patients with acute lung injury and 30 normal people, and relativity analysis was made. Results： There was significant increase levels of TNF-α, IL-10, and PAF in patients with acute lung injury. Conclusion： Serum TNF-α ,PAF, IL-10 play an important role in lung injury. This prompts three kinds of indicators have potential application value in diagnosis, treatment and prognosis of lung injury.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2009年第6期772-774,共3页
Journal of Chongqing Medical University
作者简介
李晓亮（1982-），男，硕士，研究方向：胸心外科。
通讯作者：向小勇，男，教授，E-mail：Charliexiang@sina.com。
