摘要
目的研究亚低温治疗急性大面积脑梗死患者的临床疗效及其对应激激素变化的影响。方法将80例急性大面积脑梗死患者,随机分为亚低温治疗组和对照组各40例。前者在常规治疗的基础上加用亚低温治疗,对照组予常规治疗。观察两组治疗前、治疗后1周促肾上腺皮质激素、皮质醇、胰高血糖素、血糖的变化及治疗前、治疗后30d临床神经功能缺损评分。结果两组治疗1周后,促肾上腺皮质激素、皮质醇、胰高血糖素、血糖较前明显下降(P<0.05),亚低温治疗组和同期对照组相比,影响更明显(P<0.05)。治疗30d后,亚低温治疗组病人神经功能缺损评分改善明显好于对照组(P<0.05),治疗组的治愈率和有效率均高于对照组(P<0.05)。结论亚低温治疗可显著降低急性大面积脑梗死患者的应激反应,改善应激性疾病,明显改善患者神经功能缺损评分具有肯定的脑保护作用,降低病死率和致残率。
Objective To investigate the effects of mild hypotheimia on the clinican significance of patients with acute larage-area cerebral infarction and stress hormones. Methods 60 patients with acute larage-area cerebral infarction were randomly divided into mild hypothermia group（n = 40）and control gronp（n = 40）. The former was treated with mild hypothermia in addition to conventional treatment and the control group was given the routine therapy. The concentration of plasma adrenal cortical hormoneadreno（ACTH ） and cortieosteroid（COR） gs in two groups before and at the last week after treatment were compared and the number of Meurological deficit scores before and at the 30th day after treatment were observed. Results The concentration of serum ACTH COR GS significantly decreased at the 1st week after treatment（P〈 0.05 ）. But the therapeutic in effect mild hypothermin groups was more obivous than that in routine therapy group （P 〈 0.05 ）. The lever of meurologieal deficit scores in mild hypothermia groups were better significatively than control group （P 〈 0.05 ）. The ratio of cure and efficiency in mild hypothermia groups were beter than in control group（P 〈 0.05）. Conclusion Mild hypothermia therapy could obviously deearease stress reaction and prove the recover）, of stress diseases, ease the neurological impairment, and significantly decreased mortality and disablie rate of acute larage-area cerebral infarction patients.
出处
《中国现代医生》
2009年第15期15-16,共2页
China Modern Doctor
关键词
亚低温
急性大面积脑梗死
应激激素
疗效
Mild hypothermia
Acute larage-area cerebral infarction
Stress hormones
Efficacy
