摘要
1例75岁男性患者,因头晕、乏力、发热、咳嗽入院。诊为急性粒-单核细胞白血病,给予非格司亭和维A酸治疗。住院15d后,患者慢性阻塞性肺病加重,给予美洛西林、五水头孢唑啉钠和头孢哌酮-舒巴坦治疗之后其症状缓解。又经16d后,实验实检查示:WBC4.38×109/L,N0.71,SCr78μmol/L。患者体温为38.5℃。给予去甲万古霉素800mg静脉滴注,每12h1次,共治疗7d。治疗第5天患者尿量明显减少,为600ml/d。第7天尿量减少至300ml/d,SCr362μmol/L。尿常规:蛋白(+),红细胞(+)。停用去甲万古霉素,给予利尿剂。2d后患者肾功能恢复正常,SCr为120μmol/L。
A 75-year-old man was hospitalized with dizziness, asthenia, fever, and cough. Acute myelomonocytic leukemia was diagnosed. Filgrasting and tretinoin were given. Fifteen days after hospitalization, his chronic pulmonary obstruction was exacerbated. He was treated with mezlocillin, cefazolin sodium pentahydrate, and cefoperazone-sulbatam, and subsequently his symptoms relieved. After a further 16 days, laboratory testing revealed the following： WBC 4.38 × 10^9/L, N 0.71, and SCr 78 μmol/L. He had a body temperature of 38.5℃. The patient received an Ⅳ infusion of norvancomycin 800 mg once every 12 hours for 7 days. On day 5 of therapy, he presented with a marked reduction of urine volume which was 600 ml/day. On day 7, his urine volume decreased to 300 ml/day. His SCr was 362 μmol/L. Urinalysis revealed protein （ ＋ ） and erythrocytes（ ＋ ）. Norvancomycin was stopped and diuretics were given. Two days later, his renal function normalized and his SCr was 120μmol/L.
出处
《药物不良反应杂志》
2009年第2期129-129,共1页
Adverse Drug Reactions Journal
