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跨膜丝氨酸蛋白酶研究进展 被引量：5

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摘要 跨膜丝氨酸蛋白酶(TMPRSSs),又名II型跨膜丝氨酸蛋白酶(TTSPs)是一类定位于细胞膜上具有保守丝氨酸蛋白酶结构域的蛋白家族,哺乳动物中已发现二十多个成员。TMPRSSs基本结构类似,C端蛋白酶结构域在胞外,N端位于胞内,还拥有单跨膜结构域,差异之处在于主干区。TMPRSSs具有多种重要生理功能,功能异常可造成耳聋、癌症、贫血和高血压等多种疾病。本文对TMPRSSs基本特征、结构、生理功能及相关疾病进行综述。
作者 郭晓强
机构地区 解放军白求恩军医学院生物化学教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2009年第2期182-184,共3页 Progress in Physiological Sciences
关键词 跨膜丝氨酸蛋白酶 耳聋 癌症 贫血 高血压
分类号 Q55 [生物学—生物化学]
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参考文献9

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同被引文献53

  • 1史忠诚,李钰,张贵寅.Ⅱ型跨膜丝氨酸蛋白酶4与肿瘤[J].国外医学（遗传学分册）,2005,28(3):152-155. 被引量：2
  • 2Ke-Feng Ding,Li-Feng Sun,Wei-Ting Ge,Han-Guang Hu,Su-Zhan Zhang,Shu Zheng.Effect of SNC19/ST14qene overexpression on invasion of colorectal cancer cells[J].World Journal of Gastroenterology,2005,11(36):5651-5654. 被引量：2
  • 3Nam RK,Sugar L,Yang W,Srivastava S,Klotz LH,Yang LY,Stanimirovic A,Encioiu E,Neill M,Loblaw DA,Trachtenberg J,Narod SA,Seth A.Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for loealised prostate cancel Br J Cancer,2007,97(12):1690-1695.
  • 4Nam RK,Sugar L,Wang Z,Yang W,Kitching R,Klotz LH,Venkateswaran V,Narod SA,Seth A.Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression.Cancer Biol Ther,2007,6(1):40-45.
  • 5Paoloni-Giaeobino A,Chen HM,Peitsch MC,Rossier C,Antonarakis SE.Cloning of the TMPRSS2 gene,which encodes a novel serine protease with transmembrane,LDLRA,and SRCR domains and maps to 21q22.3.Ge-nomics,1997,44(3):309-320.
  • 6Lin B,Ferguson C,White JT,Wang S,Vessella R,True LD,Hood L,Nelson PS.Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.CancerRes,1999,59(17):4180-4184.
  • 7Vaarala MH,Porvari K,Kyll6nen A,Lukkarinen O,Vihko P.The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients:detection of mutated TMPRSS2 form in a case of aggressive disease.Int J Cancer,2001,94(5):705-710.
  • 8Afar DE,Vivanco I,Hubert RS,Kuo J,Chen E,Saffran DC,Raitano AB,Jakobovits A.Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.Cancer Res,2001,61(4):1686-1692.
  • 9De Val S,Black BL.Transcriptional control of endothelial cell development.Dev Cell,2009,16(2):180-195.
  • 10Tomlins SA,Mehra R,Rhodes DR,Smith LR,Rouiston D,Helgeson BE,Cao XH,Wei JT,Rubin MA,Shah RB,Chinnaiyan AM.TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer.Cancer Res,2006,66(7):3396-3400.

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生理科学进展
2009年 第2期

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