期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

辛伐他汀联合阿司匹林治疗缺血性小卒中患者血清神经元烯醇化酶、内皮素-1浓度变化 被引量：1

原文传递
导出
摘要 目的探讨辛伐他汀和阿司匹林在治疗及预防缺血性小卒中过程中的脑保护作用。方法将缺血性小卒中患者随机分为研究组及对照组;研究组口服辛伐他汀、阿司匹林肠溶片,对照组仅口服阿司匹林肠溶片;于治疗前、治疗6个月后检测血清内皮素-1(ET-1)、神经元烯醇化酶(NSE)浓度。结果与治疗前比较,两组血清ET-1、NSE浓度均显著降低,差异均有统计学意义(P<0.05),并且研究组6个月后上述指标的降低幅度与对照组比较,差异有统计学意义(P<0.05)。结论辛伐他汀联合阿司匹林能有效降低血清ET-1、NSE浓度,有效改善脑组织缺血损伤。
作者 解学军 崔其福 赵艳茹 赵艳丽
机构地区 赤峰学院附属医院神经内二科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第17期5276-5277,共2页 Chinese Journal of Clinicians(Electronic Edition)
关键词 卒中 阿司匹林 辛伐他汀 内皮素-1 神经元烯醇化酶
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献5

二级参考文献59

  • 1[1]Thompson EJ,Green AJ.Protein markers of brain damage[J].Multscler,1998,4 (1):5-6.
  • 2[2]McKeating EG,Andrews PJ,Mascia L.Relationship of neuron specific enolase and protein S-100 concentrations in systemic and jugular venous serum to injury severity and outcome after traumatic brain injury[J].Acta Neurochir[Suppl],1998,7 (1):117-119.
  • 3[3]Kita T,Liu L,Tanaka N,et al.The expression of tumor necrosis factoralpha in the rat brain after fluid percussive injury[J].Int J Legal Med,1997,110(6):305-311.
  • 4[4]Hardemark HG,Ericesson N,Kotwica E,et al.S-100 protein and neuron-specific enolase in CSG after experimental traumatic or focal ischemic brain damage[J].J Neurosurg,1989,71 (5 pt 1):727-731.
  • 5[5]Raabe A,Grolms C,Seifert V,et al.Serum markers of brain damage and outcome prediction in patients after severe head injury[J].Br J Neurosurg,1999,13 (1):56-59.
  • 6[6]Ingebrigtsen T,Waterloo K,Jacobsen EA,et al.Traumatic brain damage in minor head injury:relation of serum S-100 protein measurements to magnetic responance imaging and neurobehavioral outcome[J].Neurosurgery,1999,45 (3):468-475.
  • 7[7]Waterloo K,Ingebrigtsen T,Romner B.Neuropsychological function in patients with increased serum levels of protein S-l00 after minor head injury[J].Acta Neurochir,1997,139(1):26-31.
  • 8[8]Rothoerl RD,Woertgen C,Holzschuh M,et al.S-100 serum levels after minor and major head injury[J].J Trauma,1998,45(4):765-767.
  • 9[9]Hinkle DA,Baldwin SA,Scheff SW,et al.GFAP and S-100 beta expression in the cortex and hippocampus in response to mild cortical contusion[J].J Neurotrauma,1997,14(10):729-738.
  • 10[10]Butterworth RJ,Wassif WS,Sherwood RA,et al.Serum neuron-specific enolase,carnosinase and their ratio in acute stroke.An enzymatic test for predicting outcome?[J] Stroke,1996,27 (11):2064-2068.

共引文献33151

同被引文献12

  • 1David Brosh,Abid R. Assali,Aviv Mager,Avital Porter,David Hasdai,Igal Teplitsky,Eldad Rechavia,Shmuel Fuchs,Alexander Battler,Ran Kornowski.Effect of No-Reflow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction on Six-Month Mortality[J]. The American Journal of Cardiology . 2007 (4)
  • 2Andrew J. Taylor,Alex Bobik,Mark Richards,David Kaye,Geoffrey Raines,Paul Gould,Garry Jennings.Myocardial endothelin-1 release and indices of inflammation during angioplasty for acute myocardial infarction and stable coronary artery disease[J].American Heart Journal.2004(2)
  • 3Lei-Lei Chen,Hang Yin,Jun Huang.Inhibition of TGF-β1 signaling by eNOS gene transfer improves ventricular remodeling after myocardial infarction through angiogenesis and reduction of apoptosis[J]. Cardiovascular Pathology . 2007 (4)
  • 4Vandana Saini,M.K. Bhatnagar,Jayashree Bhattacharjee.??Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease(J)Disease Markers . 2011 (4)
  • 5Xi-Ming Yang,Sebastian Philipp,James M. Downey,Michael V. Cohen.??Postconditioning’s protection is not dependenton circulating blood factors or cells butinvolves adenosine receptors and requiresPI3–kinase and guanylyl cyclase activation(J)Basic Research in Cardiology . 2005 (1)
  • 6Arnaldo Poli,Raffaela Fetiveau,Pietro Vandoni,Gianfranco del Rosso,Maurizio D’Urbano,Giovanni Seveso,Francesco Cafiero,Stefano De Servi.??Integrated Analysis of Myocardial Blush and ST-Segment Elevation Recovery After Successful Primary Angioplasty: Real-Time Grading of Microvascular Reperfusion and Prediction of Early and Late Recovery of Left Ventricular Function(J)Circulation: Journal of the American Heart Association . 2002 (3)
  • 7Folsom AR,Aleksic N,Park E,et al.Prospective study of fibrinolytic factors and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. Arteriosclerosis . 2001
  • 8Fujita Masashi,Asanuma Hiroshi,Hirata Akio,Wakeno Masakatsu,Takahama Hiroyuki,Sasaki Hideyuki,Kim Jiyoong,Takashima Seiji,Tsukamoto Osamu,Minamino Tetsuo,Shinozaki Yoshiro,Tomoike Hitonobu,Hori Masatsugu,Kitakaze Masafumi.Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning. American journal of physiology. Heart and circulatory physiology . 2007
  • 9Zhao ZQ,Corvera JS,Halkos ME,et al.Inhibition of myocardial injury by ischemic postconditioning. American Journal of Physiology Heart and Circulatory Physiology . 2003
  • 10周亚峰,赵彩明,薛枫,钱晓东,程绪杰,杨向军.缺血后适应对急性心肌梗死二维结构与左心室收缩功能的影响[J].中华临床医师杂志（电子版）,2013,7(18):31-35. 被引量：4

引证文献1

二级引证文献12

中华临床医师杂志（电子版）
2012年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
关于我们 | 版权声明 | 联系我们 | 帮助中心| 意见反馈
主办单位：上海市教育委员会
技术支持：重庆维普资讯有限公司
渝公网安备 50019002500403号
使用帮助 返回顶部